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Updated: Jun 13, 2026
Stereotactically-guided Ablation of the Rat Auditory Cortex, and Localization of the Lesion in the Brain
Published on: October 11, 2017
Early APV chronic blocked alters experience-dependent plasticity of auditory spatial representation in rat auditory
Yilei Cui1, Rui Cai, Jiping Zhang
1School of Life Science, Institute of Cognitive Neuroscience, Key Laboratory of Brain Functional Genomics, Ministry of Education of China, East China Normal University, Shanghai, China.
Abstract:
Development of auditory function can be affected by environment and experience. In this study, we investigated whether the NMDA receptor mediates the plasticity of auditory spatial representation during development of the rat auditory cortex. We found that early auditory experience significantly increased the auditory spatial sensitivity of A1 neurons and induced training-dependent plasticity. Implantation of Elvax-APV in the auditory cortex gradually reduced the auditory spatial sensitivity of A1 neurons and blocked the auditory spatial plasticity induced by early auditory experience. These results indicate that the NMDA receptor has a key role in experience-dependent plasticity of auditory cortical circuits immediately after birth.
