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Monitoring Hippo Signaling Pathway Activity Using a Luciferase-based Large Tumor Suppressor (LATS) Biosensor
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Yorkie: the final destination of Hippo signaling

Hyangyee Oh1, Kenneth D Irvine

  • 1Howard Hughes Medical Institute, Waksman Institute and Department of Molecular Biology and Biochemistry, Rutgers University, Piscataway, NJ 08854, USA.

Trends in Cell Biology
|May 11, 2010
PubMed

Insights

The Hippo signaling pathway controls animal growth and prevents cancer by regulating the Yorkie/Yap protein. Recent research reveals complex mechanisms controlling Yorkie/Yap activity and gene targets.

Area of Science:

  • Developmental Biology
  • Cancer Biology
  • Molecular Signaling

Background:

  • The Hippo signaling pathway is crucial for regulating organ size during animal development.
  • Dysregulation of the Hippo pathway is implicated in various cancers.
  • Hippo signaling inhibits growth by controlling the transcriptional co-activator Yorkie (Drosophila) and Yap (vertebrates).

Purpose of the Study:

  • To review the recent advancements in understanding the regulation and function of the Yorkie/Yap transcriptional co-activator.
  • To highlight the complex mechanisms governing Yorkie/Yap activity within the Hippo signaling pathway.

Main Methods:

  • Literature review of studies on the Hippo signaling pathway and Yorkie/Yap.
  • Analysis of research on the regulation of Yorkie/Yap activity.
  • Examination of studies identifying Yorkie/Yap DNA-binding partners.

Main Results:

  • Yorkie/Yap acts as a key downstream effector of Hippo signaling, regulating growth.
  • Multiple mechanisms exist to repress Yorkie/Yap transcriptional activity.
  • Distinct DNA-binding partners direct Yorkie/Yap to specific target genes, adding complexity to its function.

Conclusions:

  • The Hippo-Yorkie/Yap pathway is a critical regulator of growth and a potential target in cancer therapy.
  • The intricate regulatory network of Yorkie/Yap, involving diverse repression mechanisms and partner proteins, underscores its complex role in development and disease.

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