Related Experiment Video
Updated: Jun 13, 2026
11:27
A Guide to Production, Crystallization, and Structure Determination of Human IKK1/α
Published on: November 2, 2018
Roles of the NF-kappaB pathway in lymphocyte development and function
Steve Gerondakis1, Ulrich Siebenlist
1The Burnet Institute, 85 Commercial Rd, Prahran, Victoria 3004, Australia. gerondakis@burnet.edu.au
Cold Spring Harbor Perspectives in Biology
|May 11, 2010
Summary
Nuclear Factor kappa B (NF-kappaB) is crucial for lymphocyte function and adaptive immunity. This pathway impacts both mature lymphocyte responses to pathogens and the development of a functional immune system.
Area of Science:
- Immunology
- Molecular Biology
- Cell Biology
Background:
- Nuclear Factor kappa B (NF-kappaB) is a key transcription factor involved in immune responses.
- NF-kappaB signaling is essential for the function of mature lymphocytes.
- The role of NF-kappaB in immune system development is also significant.
Purpose of the Study:
- To elucidate the critical functions of NF-kappaB in lymphocytes.
- To understand NF-kappaB's impact on adaptive immunity.
- To explore NF-kappaB's roles in both cell-autonomous and supportive cell contexts.
Main Methods:
- This review synthesizes existing literature on NF-kappaB.
- Focuses on functional analysis within lymphocytes and other immune cells.
- Integrates findings on NF-kappaB's role in immune system development and pathogen response.
Main Results:
- NF-kappaB is vital for mature lymphocyte responses to pathogens.
- NF-kappaB plays a critical role in shaping the immune system for adaptive responses.
- NF-kappaB exerts functions within lymphocytes and supportive cells like APCs and epithelial cells.
Conclusions:
- NF-kappaB is indispensable for adaptive immunity, influencing both lymphocyte effector functions and immune system development.
- Understanding NF-kappaB's multifaceted roles provides insights into immune regulation.
- Targeting NF-kappaB pathways may offer therapeutic strategies for immune-related diseases.
More Related Videos
Related Concept Videos
02:26NF-κB-dependent Signaling Pathway
The transcription factor NF-κB was discovered in 1986 in the lab of Nobel laureate Professor David Baltimore, for its interaction with the immunoglobulin light chain enhancer in B-cells. After more than three decades of study, it is now evident that NF-κB regulates the expression of over 100 genes. Most of these genes play an essential role in the innate and adaptive immune responses as well as the inflammatory responses of animals.
NF-κB-dependent Signaling Mechanism
The heterodimer of NF-κB...
NF-κB-dependent Signaling Mechanism
The heterodimer of NF-κB...
02:26NF-kB-dependent Signaling Pathway
The transcription factor NF-κB was discovered in 1986 in the lab of Nobel laureate Professor David Baltimore, for its interaction with the immunoglobulin light chain enhancer in B-cells. After more than three decades of study, it is now evident that NF-κB regulates the expression of over 100 genes. Most of these genes play an essential role in the innate and adaptive immune responses as well as the inflammatory responses of animals.
NF-κB-dependent Signaling Mechanism
The heterodimer of NF-κB...
NF-κB-dependent Signaling Mechanism
The heterodimer of NF-κB...
01:31The Intrinsic Apoptotic Pathway
Internal cellular stress, such as cellular injury or hypoxia, triggers intrinsic apoptosis. The B-cell lymphoma 2 (Bcl-2) family of proteins are the primary regulators of the intrinsic apoptotic pathway. For example, during DNA damage, checkpoint proteins, such as Ataxia Telangiectasia Mutated (ATM protein) and Checkpoints Factor-2 (Chk2) proteins, are activated. These proteins phosphorylate p53 which further activates pro-apoptotic proteins, such as Bax, Bak, PUMA, and Noxa, and inhibits...
02:54Canonical Wnt Signaling Pathway
The gene encoding the main signaling molecules of the Wnt signaling pathways (the Wnt proteins) was discovered almost four decades ago by Nüsslein-Volhard and Wieschaus. They identified and originally named the gene "wingless" (wg) after a phenotype discovered during their landmark genetic screen in Drosophila for body pattern defects. At around the same time, another researcher named Harold Varmus found that a murine tumor virus activates the mammalian wg homolog, Int-1, which results in tumor...
01:17The Extrinsic Apoptotic Pathway
The extrinsic apoptotic pathway is initiated when extracellular death-inducing signals, such as specific cytokines, activate the death receptors expressed on the cell surface. The immune cells involved in this pathway are natural killer cells (NK cells) and cytotoxic T-lymphocytes. NK cells are critical in innate immune response, while cytotoxic T-lymphocytes are associated with adaptive immune response. These cells recognize specific receptors expressed on the altered cells and activate...
01:41Non-Canonical Wnt Signaling Pathways
Wnt is a zygotic effect gene that is expressed during very early embryonic development. It regulates various processes in animals starting from early development through the adult stage, such as organogenesis in the embryo and maintenance of neuronal and blood stem cells. Wnt proteins can induce a wide variety of intracellular pathways depending upon the specific abilities of different Wnt ligands to form a complex with shared and cognate receptors in the presence of different co-receptors. The...