Related Experiment Video

Updated: Jun 13, 2026

Assessment of the Efficacy of An Osteopathic Treatment in Infants with Biomechanical Impairments to Suckling
07:11

Assessment of the Efficacy of An Osteopathic Treatment in Infants with Biomechanical Impairments to Suckling

Published on: February 5, 2019

Tolerance of baby cleansers in infants: a randomized controlled trial

Ma Victoria Dizon1, Carlos Galzote, Ricco Estanislao

  • 1University of Santo Tomas Hospital, Manila, Philippines. mdizonmd@hotmail.com

Indian Pediatrics
|May 11, 2010
PubMed

Insights

Johnsons Top-to-Toe cleanser (JTT) and Sebamed Baby Liquid cleanser (SM) were found to be safe and effective for infant skin. Both cleansers, along with tap water, showed no adverse effects in a two-week trial.

Area of Science:

  • Dermatology
  • Pediatrics
  • Consumer Product Testing

Background:

  • Infant skin is delicate and requires gentle cleansing products.
  • Assessing the tolerability of new baby cleansers is crucial for preventing adverse skin reactions.

Purpose of the Study:

  • To evaluate the tolerability of Johnsons Top-to-Toe cleanser (JTT) compared to Sebamed Baby Liquid cleanser (SM) and tap water on infantile skin.
  • To assess clinical and instrumental parameters of skin health and consumer satisfaction.

Main Methods:

  • A randomized controlled trial involving 180 healthy infants.
  • Participants were divided into three groups using JTT, SM, or tap water as whole body cleansers twice weekly for two weeks.
  • Skin assessments included clinical evaluation, instrumental measurements (moisture, pH, TEWL), and parental feedback.

Main Results:

  • No significant erythema, edema, dryness, or scaling was observed with any of the tested cleansers.
  • Parents reported no side effects for any of the interventions.
  • All three interventions were found to be efficacious and well-tolerated by infants.

Conclusions:

  • Johnsons Top-to-Toe cleanser (JTT) and Sebamed Baby Liquid cleanser (SM) are well-tolerated and safe for use on infantile skin.
  • Gentle cleansing with mild products or even tap water is suitable for healthy infant skin.
  • The study supports the safety profile of JTT for infant skincare routines.

More Related Videos

Noninvasive Sampling of Mucosal Lining Fluid for the Quantification of In Vivo Upper Airway Immune-mediator Levels05:31

Noninvasive Sampling of Mucosal Lining Fluid for the Quantification of In Vivo Upper Airway Immune-mediator Levels

Published on: August 7, 2017

Related Concept Videos

Development of Human Microbiota01:30

Development of Human Microbiota

The human microbiota begins developing at birth and undergoes continual change as we age. Infancy marks a critical period of microbial sensitivity, offering a “window of opportunity” during which beneficial microbes help mature the immune system. By age three, children typically develop a more stable and diverse microbial community. Newborns acquire microbes from their immediate environment; vaginal delivery favors maternal vaginal microbes, while cesarean births favor microbes from the skin...
Drug Dosing: Infants and Children01:29

Drug Dosing: Infants and Children

Pediatric patient dosages diverge from adults due to disparities in body surface area, total body water, and extracellular fluid per kilogram of body weight. The dosing regimen considers the variations in pharmacokinetics and pharmacology across distinct age groups, encompassing preterm newborns, infants, young children, older children, and adolescents. Calculation of pediatric patient doses is predicated on determining body surface area, which exhibits a superior correlation with the child's...
Upper Respiratory Drugs: Antitussives, Expectorants, and Mucolytics01:23

Upper Respiratory Drugs: Antitussives, Expectorants, and Mucolytics

Respiratory symptoms, such as congestion and cough, commonly accompany respiratory tract conditions. Various medications, such as antitussives, expectorants, and mucolytics, play crucial roles in providing relief.
Antitussives include codeine, dextromethorphan (Robitussin), and benzonatate (Tessalon). Codeine and dextromethorphan exert their effects centrally by suppressing the cough reflex center in the medulla.  Benzonatate operates peripherally within the respiratory tract by anesthetizing...
Microbiota Modulation by Antibiotics01:21

Microbiota Modulation by Antibiotics

Antibiotics have revolutionized modern medicine by saving countless lives from bacterial infections. However, their widespread use has inadvertently harmed the delicate balance of the human gut microbiota. The gut microbiota, a complex community of bacteria, archaea, viruses, and fungi, plays a vital role in regulating metabolism, immune responses, and maintaining intestinal health. Antibiotics, especially broad-spectrum types, disrupt this ecosystem by eradicating both harmful and beneficial...
Development of Immunocompetence01:22

Development of Immunocompetence

The initiation of cell-mediated immunity can be observed as early as the third month of fetal growth, with active antibody-mediated immunity following approximately one month later.
The initial cells that migrate from the fetal thymus settle within the skin and epithelial tissues lining the mouth, digestive tract, and in females, the uterus and vagina. These cells, including skin-based dendritic cells, serve as antigen-presenting cells, playing a key role in T cell activation.
Subsequent T...