Related Experiment Video

Updated: Jun 13, 2026

Targeted Plasma Membrane Delivery of a Hydrophobic Cargo Encapsulated in a Liquid Crystal Nanoparticle Carrier
10:16

Targeted Plasma Membrane Delivery of a Hydrophobic Cargo Encapsulated in a Liquid Crystal Nanoparticle Carrier

Published on: February 8, 2017

Peptide-mediated liposomal drug delivery system targeting tumor blood vessels in anticancer therapy

Han-Chung Wu1, De-Kuan Chang

  • 1Institute of Cellular and Organismic Biology, Academia Sinica, Taipei 11529, Taiwan.

Journal of Oncology
|May 11, 2010
PubMed

Insights

Targeting tumor blood vessels with peptide-conjugated liposomes offers a promising anti-cancer strategy. This approach enhances conventional chemotherapy by delivering drugs directly to tumor endothelial cells, minimizing toxicity and improving efficacy.

Area of Science:

  • Oncology
  • Biotechnology
  • Nanomedicine

Background:

  • Solid tumors require neovascularization for growth.
  • Tumor endothelial cells express unique molecules, making them targets for anti-cancer therapies.
  • Conventional chemotherapy can be improved by targeted drug delivery systems.

Purpose of the Study:

  • To review methods for targeting tumor blood vessels using peptide-conjugated liposomes.
  • To explore the potential of these systems in anti-angiogenic cancer therapy.
  • To highlight the advantages of liposome-based drug delivery for cancer treatment.

Main Methods:

  • Review of current and potential methods for targeting tumor vasculature.
  • Focus on peptide-conjugated liposomes as drug delivery vehicles.
  • Analysis of mechanisms for destroying tumor blood vessels.

Main Results:

  • Peptide-conjugated liposomes can specifically target tumor endothelial cells.
  • These liposomes can encapsulate anticancer drugs for targeted delivery.
  • The approach offers potential for high efficacy and low toxicity.

Conclusions:

  • Targeting tumor blood vessels with peptide-conjugated liposomes is a viable anti-cancer strategy.
  • This method enhances the effectiveness of conventional chemotherapeutics.
  • Liposome-based drug delivery systems show promise for improved cancer therapy.

More Related Videos

Intravital Microscopy of Tumor-associated Vasculature Using Advanced Dorsal Skinfold Window Chambers on Transgenic Fluorescent Mice08:52

Intravital Microscopy of Tumor-associated Vasculature Using Advanced Dorsal Skinfold Window Chambers on Transgenic Fluorescent Mice

Published on: January 19, 2018

Related Concept Videos

Modified-Release Drug Delivery Systems: Site-Targeted01:24

Modified-Release Drug Delivery Systems: Site-Targeted

Site-targeted drug delivery systems enhance therapeutic efficacy while minimizing systemic toxicity and treatment costs. Unlike conventional methods, these systems ensure precise drug delivery, improving bioavailability and reducing side effects. Targeted drug delivery is classified into three levels. First-order targeting directs drugs to the capillary beds of specific organs or tissues. Second-order targets specific cell types, such as tumor cells, using receptor-mediated interactions.
Targeted Cancer Therapies02:57

Targeted Cancer Therapies

The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against specific...
Targeted Cancer Therapies02:57

Targeted Cancer Therapies

The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against specific...
Site-Targeted Drug Delivery Systems: Polymeric Carriers01:24

Site-Targeted Drug Delivery Systems: Polymeric Carriers

Polymeric carriers enhance targeted drug delivery by increasing efficacy while minimizing off-target effects. These carriers comprise a biodegradable polymeric backbone integrated with functional elements that enable targeting, improve physicochemical properties, and regulate drug release.Targeting MechanismsThe targeting ability of polymeric carriers is mediated by a homing device, which is a molecular recognition component designed to selectively bind to specific tissues or cells. Monoclonal...
Tumor Immunotherapy01:27

Tumor Immunotherapy

Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.