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[The importance of preanalytics for the coagulation laboratory]
Georg Endler1, G Slavka, T Perkmann
1Medical University of Vienna, Department of Medical and Chemical Laboratory Diagnostics, AKH-Wien, 1090 Wien, Austria. Georg.Endler@meduniwien.ac.at
Hamostaseologie
|May 11, 2010
Summary
Coagulation testing faces sample rejection and variability issues due to complex preanalytics. Laboratories should develop tailored sample collection manuals, considering factors like tube type and reagents, to improve test accuracy.
Area of Science:
- Clinical Chemistry
- Hematology
- Laboratory Medicine
Context:
- Coagulation testing is prone to preanalytical errors, leading to sample rejections and high variability.
- Existing guidelines for standardizing preanalytical procedures are often difficult to implement in routine laboratory settings due to technical and logistical constraints.
Purpose:
- This manuscript discusses critical issues in the preanalytical phase of coagulation testing, including sample collection, handling, and transportation.
- It aims to provide insights into minimizing errors and improving the reliability of coagulation test results.
Summary:
- Routine coagulation tests like prothrombin time and partial prothrombin time are sensitive to variables such as tube type, manufacturer, reagents, and analyzer systems.
- The stability and variability of these tests are significantly influenced by preanalytical factors.
Impact:
- Implementing laboratory-specific sample collection manuals, based on internal evaluations and published data, is recommended.
- This approach can enhance the quality and consistency of coagulation test results, reducing rejections and improving diagnostic accuracy.
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