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Updated: Jun 13, 2026
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Bead Aggregation Assays for the Characterization of Putative Cell Adhesion Molecules
Published on: October 17, 2014
Ig superfamily cell adhesion molecules in the brain
1Institute of Zoology, University of Zurich, Winterthurerstrasse 190, 8057, Zurich, Switzerland, Esther.Stoeckli@zool.unizh.ch.
Handbook of Experimental Pharmacology
|May 11, 2010
Summary
Cell adhesion molecules of the immunoglobulin superfamily (IgSF CAMs) are crucial for brain development. These molecules play diverse roles beyond simple cell adhesion, including axon guidance and synapse formation.
Area of Science:
- Neuroscience
- Molecular Biology
- Developmental Biology
Background:
- Cell adhesion molecules of the immunoglobulin superfamily (IgSF CAMs) were initially identified for their role in cell-cell adhesion.
- Their functions have evolved from simple adhesion to complex signaling roles in neural development.
Purpose of the Study:
- To review the evolving understanding of IgSF CAMs' roles in neuroscience.
- To highlight the diverse signaling mechanisms associated with IgSF CAMs.
Main Methods:
- Literature review and synthesis of research findings on IgSF CAMs.
Main Results:
- IgSF CAMs are involved in cell segregation, axon growth, cell migration, axon guidance, and synapse formation/maturation.
- The signaling mechanisms associated with IgSF CAMs are diverse and complex.
Conclusions:
- IgSF CAMs are versatile molecules essential for brain development.
- Their multifaceted roles extend beyond adhesion to intricate signaling pathways regulating neural circuit formation.
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