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Late asthmatic responses after exercise challenge are reproducible
B Speelberg1, E A Panis, D Bijl
1Dutch Asthma Center, Davos, Switzerland.
The Journal of Allergy and Clinical Immunology
|June 1, 1991
Summary
Late asthmatic reactions (LAR) following exercise challenge (EC) in asthma patients are reproducible. This study found that 73% of patients who experienced an LAR after an initial EC showed a reproducible reaction upon re-challenge.
Area of Science:
- Pulmonology
- Respiratory Medicine
- Clinical Immunology
Background:
- Exercise challenge is a common method to induce asthma symptoms.
- Late asthmatic reactions (LAR) are a delayed response to stimuli, distinct from immediate reactions.
- Understanding the reproducibility of LAR after exercise challenge (EC) is crucial for asthma management and research.
Purpose of the Study:
- To document the reproducibility of late asthmatic reactions (LAR) after exercise challenge (EC) in hospitalized asthma patients.
- To assess the consistency of LAR occurrence in individuals over time.
- To determine the prevalence of reproducible LAR following EC.
Main Methods:
- Eighty-three hospitalized asthma patients underwent a standardized 8-minute bicycling exercise challenge.
- Late asthmatic reaction (LAR) diagnosis was based on a ≥20% fall in peak expiratory flow rate at multiple time points post-EC compared to a control day.
- Patients who experienced an LAR were rechallenged 21–150 days later to assess reproducibility, with no changes in their therapy regimen.
Main Results:
- 11 out of 83 patients (13.3%) initially experienced a late asthmatic reaction (LAR) after exercise challenge (EC).
- Of those who had an initial LAR, 8 patients (73%) demonstrated a reproducible LAR upon rechallenge.
- While reproducible, the timing of the LAR after the second EC varied compared to the first EC.
Conclusions:
- Late asthmatic reactions (LAR) following exercise challenge (EC) occur in a significant proportion of asthma patients.
- The occurrence of LAR after EC is reproducible in a majority of patients who experience it.
- These findings support the use of EC as a reliable method for inducing and studying reproducible LAR in asthma.
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