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Related Experiment Videos

Androgen receptors in normal and pathological thyroids.

M Marugo1, G Torre, D Bernasconi

  • 1Cattedra di Fisiopatologia Endocrina e Cattedra di Endocrinologia e Patologia Costituzionale, Genova, Italy.

Journal of Endocrinological Investigation
|January 1, 1991
PubMed
Summary

Androgen receptors (AR) are present in normal and nodular thyroid tissues. Nuclear AR levels are higher in normal thyroid tissue, especially in men, suggesting androgens influence thyroid growth and potentially protect against thyroid disease.

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Area of Science:

  • Endocrinology
  • Molecular Biology
  • Thyroid Research

Background:

  • Androgen receptors (AR) play a crucial role in mediating the effects of androgens.
  • Thyroid tissue is known to be influenced by various hormones, but the role of androgens is less understood.
  • Understanding androgen receptor presence is key to exploring androgenic influence on thyroid function and disease.

Purpose of the Study:

  • To investigate the presence and distribution of cytosolic and nuclear androgen receptors (AR) in normal and nodular human thyroid tissues.
  • To compare AR levels between normal and diseased (nodular) thyroid tissues.
  • To explore potential sex-based differences in AR content within thyroid tissue.

Main Methods:

  • Tissue samples from 12 women and 6 men, including normal thyroid and benign nodular tissue, were analyzed.

Related Experiment Videos

  • The single saturation point assay using [3H] Methyltrienolone was employed to quantify AR.
  • Cytosolic and nuclear AR concentrations were determined in all samples.

    • Main Results:

    • Androgen receptors (AR) were detected in all examined thyroid tissue samples (both normal and nodular).
    • Nuclear AR content was significantly higher in normal thyroid tissue compared to nodular tissue (p < 0.01).
    • Normal thyroid tissue from men exhibited significantly higher nuclear AR levels than that from women (p < 0.05).

    Conclusions:

    • Androgens appear to influence thyroid tissue, with higher nuclear AR concentrations in normal male thyroid tissue.
    • Reduced AR levels in nodular and goitrous tissues suggest androgens may have an antagonistic role in thyroid growth.
    • These findings may explain the lower incidence of thyroid diseases in men and support an anti-proliferative effect of androgens on thyroid tissue.