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Related Concept Videos

Depressive Disorders: Etiology01:27

Depressive Disorders: Etiology

Depressive disorders result from a complex interplay of biological, psychological, and sociocultural factors, each contributing uniquely to the development and persistence of the condition. Understanding these factors provides critical insight into the multifaceted nature of depression.
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Depressive disorders are a group of mental health conditions characterized by pervasive feelings of sadness, diminished pleasure in life, and a significant impact on daily functioning. These conditions are most prevalent in individuals during their 30s and affect women at twice the rate of men. Contrary to popular belief, younger individuals are generally more susceptible to these disorders than older adults. Two key types of depressive disorders include Major Depressive Disorder (MDD) and...
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Depression is a prevalent mental illness marked by persistent sadness and lack of interest in previously enjoyable activities. It can take several forms, including major depression, persistent depressive disorder, and bipolar I and II disorders. Symptoms range from emotional changes like chronic worry to physical changes like sleep disturbances and suicidal thoughts. From a neurobiological perspective, depression is believed to be triggered by abnormalities in the brain's prefrontal cortex,...
Long-term Depression01:03

Long-term Depression

Long-term depression, or LTD, is one of the ways by which synaptic plasticity—changes in the strength of chemical synapses—can occur in the brain. LTD is the process of synaptic weakening that occurs over time between pre and postsynaptic neuronal connections. The synaptic weakening of LTD works in opposition to synaptic strengthening by long-term potentiation (LTP) and together are the main mechanisms that underlie learning and memory.
Calcium Ion Concentration Mechanism
If over time, all...
Long-term Depression01:05

Long-term Depression

Long-term depression, or LTD, is one of the ways by which synaptic plasticity—changes in the strength of chemical synapses—can occur in the brain. LTD is the process of synaptic weakening that occurs over time between pre and postsynaptic neuronal connections. The synaptic weakening of LTD works in opposition to synaptic strengthening by long-term potentiation (LTP) and together are the main mechanisms that underlie learning and memory.
Diagnostic and Statistical Manual of Mental Disorders (DSM)01:27

Diagnostic and Statistical Manual of Mental Disorders (DSM)

The Diagnostic and Statistical Manual of Mental Disorders (DSM) serves as the primary classification system for mental health disorders, providing standardized diagnostic criteria for clinicians and researchers. First published by the American Psychiatric Association (APA) in 1952, the DSM has undergone several revisions to reflect evolving psychiatric understanding. The fifth edition, DSM-5, released in 2013, introduced key updates that expanded diagnostic categories and modified diagnostic...

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Updated: Jun 13, 2026

A New Method for Inducing a Depression-Like Behavior in Rats
07:57

A New Method for Inducing a Depression-Like Behavior in Rats

Published on: February 22, 2018

[Depression and somatic comorbidity].

Brenda W J H Penninx1, Richard van Dyck

  • 1VU Medisch Centrum, afd. Psychiatrie en EMGO+ Instituut, Amsterdam, The Netherlands. b.penninx@vumc.nl

Nederlands Tijdschrift Voor Geneeskunde
|May 12, 2010
PubMed
Summary
This summary is machine-generated.

Depression increases the risk of physical health problems like heart disease and diabetes. Monitoring physical health is crucial when treating depression to address potential somatic conditions.

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An Unpredictable Chronic Mild Stress Protocol for Instigating Depressive Symptoms, Behavioral Changes and Negative Health Outcomes in Rodents
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An Unpredictable Chronic Mild Stress Protocol for Instigating Depressive Symptoms, Behavioral Changes and Negative Health Outcomes in Rodents

Published on: December 2, 2015

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Last Updated: Jun 13, 2026

A New Method for Inducing a Depression-Like Behavior in Rats
07:57

A New Method for Inducing a Depression-Like Behavior in Rats

Published on: February 22, 2018

An Unpredictable Chronic Mild Stress Protocol for Instigating Depressive Symptoms, Behavioral Changes and Negative Health Outcomes in Rodents
06:55

An Unpredictable Chronic Mild Stress Protocol for Instigating Depressive Symptoms, Behavioral Changes and Negative Health Outcomes in Rodents

Published on: December 2, 2015

Area of Science:

  • Psychiatry
  • Internal Medicine
  • Epidemiology

Context:

  • Depression is frequently associated with an increased risk of developing somatic conditions.
  • Mechanisms linking depression and somatic comorbidity include lifestyle factors and pathophysiological disturbances.
  • Alternative explanations involve genetic factors, iatrogenic effects, and somatic depression.

Purpose:

  • To explore the relationship between depression and somatic comorbidity.
  • To discuss potential mediating mechanisms and alternative explanations for this association.
  • To emphasize the importance of monitoring somatic health in depressed patients.

Summary:

  • Depression elevates the risk for somatic conditions like cardiovascular disease, diabetes, and obesity.
  • Mediating factors include unhealthy lifestyles and pathophysiological disturbances.
  • Alternative explanations encompass genetic pleiotropy, iatrogenic effects, and somatic depression, where somatic conditions cause depressive symptoms.

Impact:

  • Highlights the need for integrated care addressing both mental and physical health in depression.
  • Suggests that monitoring somatic health is essential in the clinical management of depression.
  • Underscores the necessity for further research into preventive interventions for somatic comorbidity in depression.