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Related Concept Videos

Chronic Kidney Disease I: Introduction01:25

Chronic Kidney Disease I: Introduction

Chronic Kidney Disease (CKD) arises when the kidneys progressively lose their ability to function, ultimately leading to end-stage renal disease. At this advanced stage, the kidneys can no longer filter waste or maintain essential body functions, requiring renal replacement therapy (RRT) through dialysis or a kidney transplant for survival.Early-stage chronic kidney disease and detection challengesIn CKD's early stages, symptoms often remain absent because healthy nephrons compensate for...
Chronic Kidney Disease III: Interprofessional Care01:28

Chronic Kidney Disease III: Interprofessional Care

Chronic kidney disease (CKD) requires collaborative and comprehensive management. CKD progresses through stages and can lead to end-stage kidney disease (ESKD) if untreated. Interprofessional collaboration and patient education are crucial, enabling patients to manage their health and improve their quality of life.Diagnostic approach for chronic kidney diseaseThe diagnosis of CKD primarily focuses on the glomerular filtration rate (GFR), which assesses kidney function by measuring how well...
Chronic Kidney Disease II: Clinical Manifestations01:24

Chronic Kidney Disease II: Clinical Manifestations

Chronic Kidney Disease (CKD) progressively impairs multiple body systems due to the accumulation of uremic toxins, which disrupt cellular functions across various organs.Neurologic symptomsNeurologic symptoms often arise early in CKD, as uremic toxin buildup drives changes in cognitive and motor functions. Patients frequently experience fatigue, headache, confusion, difficulty concentrating, and, in severe cases, seizures. Peripheral neuropathy commonly manifests as burning sensations in the...
Chronic Kidney Disease IV: Nursing Management01:18

Chronic Kidney Disease IV: Nursing Management

Nursing management is essential for preventing complications, maintaining stability, and improving patients' quality of life in chronic kidney disease (CKD). By using a structured approach, nurses help slow CKD progression and support effective patient care​.1. Comprehensive patient assessmentEffective management begins with nurses reviewing the patient’s medical history, and identifying key risk factors like diabetes, hypertension, and nephrotoxic drug use. Nurses assess signs of fluid...
Diabetic Nephropathy01:28

Diabetic Nephropathy

Definition Diabetic nephropathy is a chronic kidney complication that results from prolonged hyperglycemia.Prevalence It is the most common cause of chronic kidney disease (CKD) and end-stage renal disease (ESRD) worldwide, affecting up to half of individuals with diabetes.Pathophysiology • Sustained hyperglycemia triggers multiple hemodynamic and metabolic changes in the kidney. • Early in the disease, increased renal blood flow and glomerular hyperfiltration occur due to afferent arteriolar...
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Kidney Transplant III: Nursing Management

Postoperative Nursing Management for Kidney Transplant PatientsPostoperative nursing management care includes monitoring the surgical site, encouraging early movement, and promoting lung health through breathing exercises. Nurses also administer prescribed medications like H2-blockers, such as famotidine, or proton pump inhibitors, like omeprazole, to help prevent gastrointestinal ulcers and bleeding. Fungal infections in the mouth and bladder can result from immunosuppressive and antibiotic...

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Related Experiment Video

Updated: Jun 13, 2026

5/6 Nephrectomy Using Sharp Bipolectomy Via Midline Laparotomy in Rats
05:34

5/6 Nephrectomy Using Sharp Bipolectomy Via Midline Laparotomy in Rats

Published on: April 4, 2025

[A woman with progressive kidney disfunction].

Y Xiaoye Zhu1, Ben G F Heggelman

  • 1Meander Medisch Centrum, afd. Radiologie, Amersfoort, The Netherlands. xiaoyezhu@hotmail.com

Nederlands Tijdschrift Voor Geneeskunde
|May 12, 2010
PubMed
Summary

Lithium treatment for bipolar disorder can cause kidney damage, known as lithium-induced nephropathy. This case highlights the importance of monitoring renal function in patients receiving long-term lithium therapy.

Area of Science:

  • Nephrology
  • Psychiatry
  • Pharmacology

Background:

  • Bipolar disorder is a chronic mental health condition often managed with mood stabilizers.
  • Lithium carbonate is a first-line treatment for bipolar disorder, effective in managing manic and depressive episodes.
  • Long-term lithium use is associated with potential adverse effects, including renal complications.

Observation:

  • A 57-year-old female patient with a history of bipolar disorder presented with a decline in kidney function.
  • Clinical evaluation indicated the cause of renal impairment was lithium-induced nephropathy.
  • The patient's presentation underscores a known but critical side effect of lithium therapy.

Findings:

  • The patient's decreasing renal function was directly attributed to lithium-induced nephropathy.

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Published on: June 23, 2015

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Last Updated: Jun 13, 2026

5/6 Nephrectomy Using Sharp Bipolectomy Via Midline Laparotomy in Rats
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Use of Ultra-high Field MRI in Small Rodent Models of Polycystic Kidney Disease for In Vivo Phenotyping and Drug Monitoring
07:35

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Published on: June 23, 2015

  • This case confirms the nephrotoxic potential of lithium, even in patients with managed bipolar disorder.
  • Diagnostic workup identified specific markers consistent with chronic kidney injury from lithium exposure.

    • Implications:

    • Regular renal function monitoring is crucial for patients on long-term lithium therapy.
    • Early detection of lithium-induced nephropathy can guide treatment adjustments and potentially prevent irreversible kidney damage.
    • This case emphasizes the need for a balanced approach, weighing the therapeutic benefits of lithium against its renal risks in bipolar disorder management.