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Updated: Jun 13, 2026

Magnetic Resonance Imaging of Multiple Sclerosis at 7.0 Tesla
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Magnetic Resonance Imaging of Multiple Sclerosis at 7.0 Tesla

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MRI texture analysis in multiple sclerosis: toward a clinical analysis protocol.

Lara C V Harrison1, Minna Raunio, Kirsi K Holli

  • 1Medical Imaging Center, Tampere University Hospital, Teiskontie 35, Tampere, Finland. lara.harrison@tut.fi

Academic Radiology
|May 12, 2010
PubMed
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Magnetic resonance imaging (MRI) texture analysis accurately differentiates multiple sclerosis lesions from white matter. The protocol is robust, showing tolerance to variations in data acquisition for clinical use.

Area of Science:

  • Neuroimaging
  • Radiology
  • Biomedical Engineering

Background:

  • Magnetic resonance imaging (MRI)-based texture analysis is effective for classifying multiple sclerosis (MS) lesions.
  • Understanding the robustness of texture analysis protocols is crucial for clinical application in MS management.

Purpose of the Study:

  • To evaluate the sensitivity of MRI texture analysis steps to variations in data acquisition.
  • To determine which aspects of texture analysis are tolerant to interference in the context of multiple sclerosis.

Main Methods:

  • Utilized MRI datasets from 38 multiple sclerosis patients.
  • Compared three imaging sequences and assessed variance between slices and region of interest drawing methods.
  • Employed MaZda software for texture analysis and statistical tests to classify white matter and MS lesions.

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Last Updated: Jun 13, 2026

Magnetic Resonance Imaging of Multiple Sclerosis at 7.0 Tesla
08:51

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Published on: February 19, 2021

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Published on: July 19, 2019

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Main Results:

  • MRI texture analysis achieved high accuracy (96%-100%) in distinguishing MS plaques from white matter using nonlinear discriminant analysis.
  • Classification results were not significantly affected by imaging sequences or anatomical levels.
  • Standardized regions of interest demonstrated tolerance to intra-tissue variance.

Conclusions:

  • A standardized MRI texture analysis protocol with fixed imaging sequence and anatomical levels is a promising quantitative tool for evaluating MS lesions.
  • The protocol shows robustness for clinical application in multiple sclerosis assessment.