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Related Concept Videos

Skin Cancer01:30

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Skin cancer is a type of cancer that occurs when there is an abnormal growth of skin cells, usually triggered by damage to the DNA within the skin cells. It is primarily caused by exposure to ultraviolet (UV) radiation from the sun or artificial sources like tanning beds. Skin cancer is the most common type of cancer worldwide, and its incidence continues to rise.
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Skin is the first line of defense and encounters a variety of microbes. Some pathogenic strains are often the cause of a broad range of infections of the skin and other body systems. These conditions can affect people of all ages and may have different causes, including genetic factors, infections, autoimmune reactions, environmental factors, and lifestyle choices.
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Several factors can increase the risk of cancer in an individual. About 50% of cancer cases can be prevented by adopting a healthy lifestyle, regular exercise, eating healthy, and following a modest cancer prevention diet. Epidemiological studies have consistently shown that populations with vegetable and fruit-rich diets have reduced the incidence of cancer. On the other hand, populations who have a diet rich in animal fat, red meat, junk food, or high calories are predisposed to cancer.
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Chemical-Induced Skin Carcinogenesis Model Using Dimethylbenz[a]Anthracene and 12-O-Tetradecanoyl Phorbol-13-Acetate DMBA-TPA
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Clinical and Histopathological Risk Factors for Multiple Cutaneous Squamous Cell Carcinomas.

Marika Lounas1,2, Tiina Luukkaala3,4, Teea Salmi1,2

  • 1Department of Dermatology, Tampere University Hospital, Wellbeing Services County of Pirkanmaa, Tampere, Finland.

Journal of Cutaneous Medicine and Surgery
|March 10, 2026
PubMed
Summary
This summary is machine-generated.

About 20% of patients with cutaneous squamous cell carcinoma (cSCC) develop multiple tumors. Men and patients with actinic keratosis, Bowen's disease, or basal cell carcinoma (BCC) are more likely to have multiple cSCCs.

Keywords:
Bowen’s diseaseactinic keratosiscutaneous squamous cell carcinomakeratinocyte carcinomanonmelanoma skin cancer

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Intramucosal Inoculation of Squamous Cell Carcinoma Cells in Mice for Tumor Immune Profiling and Treatment Response Assessment
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Area of Science:

  • Dermatology
  • Oncology
  • Epidemiology

Background:

  • Cutaneous squamous cell carcinoma (cSCC) can present as multiple tumors in some patients.
  • Factors influencing the development of multiple cSCCs are not well understood.

Purpose of the Study:

  • To determine the proportion of patients with more than one cSCC tumor.
  • To identify patient- and tumor-related factors associated with multiple cSCC development.

Main Methods:

  • Retrospective analysis of histopathologically diagnosed cSCC cases from Pirkanmaa, Finland (2006-2020).
  • Data collection included patient demographics, tumor characteristics, and medical history from clinical records.

Main Results:

  • 1421 patients and 1988 cSCC tumors were identified; 20% (285 patients) had multiple cSCCs.
  • Multiple cSCCs were associated with male gender, actinic keratosis, Bowen's disease, basal cell carcinoma (BCC), and tumor invasion depth >2mm.
  • The median time to a second cSCC was 13 months, with 71% occurring at the same site.

Conclusions:

  • Multiple cSCCs affect 20% of patients, often co-occurring with premalignant lesions and BCCs.
  • Identifying these associated factors can aid in risk stratification and management of cSCC patients.