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Related Concept Videos

Nephrons01:10

Nephrons

The kidneys are intricate organs with millions of working units known as nephrons. Each nephron features two major structures: the renal corpuscle, which facilitates blood plasma filtration, and the renal tubule, which handles the glomerular filtrate. Blood supply is directly linked to the nephrons. The renal corpuscle consists of the glomerulus, a capillary network, and the Bowman's capsule, a double-walled epithelial structure that encases the glomerulus. The filtering of blood plasma happens...

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Related Experiment Video

Updated: Jun 13, 2026

MicroRNA In situ Hybridization for Formalin Fixed Kidney Tissues
12:21

MicroRNA In situ Hybridization for Formalin Fixed Kidney Tissues

Published on: November 30, 2013

MicroRNAs in kidney development: lessons from the frog.

Oliver Wessely1, Raman Agrawal, Uyen Tran

  • 1Department of Cell Biology and Anatomy, LSU Health Sciences Center, New Orleans, LA, USA. owesse@lsuhsc.edu

RNA Biology
|May 12, 2010
PubMed
Summary
This summary is machine-generated.

MicroRNAs (miRNAs) are essential regulators of kidney development and function. These small RNAs fine-tune gene expression, ensuring proper kidney formation and maintenance throughout life, even during injury.

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Isolation and Culture of Cells from the Nephrogenic Zone of the Embryonic Mouse Kidney
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Isolation and Culture of Cells from the Nephrogenic Zone of the Embryonic Mouse Kidney

Published on: April 22, 2011

Related Experiment Videos

Last Updated: Jun 13, 2026

MicroRNA In situ Hybridization for Formalin Fixed Kidney Tissues
12:21

MicroRNA In situ Hybridization for Formalin Fixed Kidney Tissues

Published on: November 30, 2013

Isolation and Culture of Cells from the Nephrogenic Zone of the Embryonic Mouse Kidney
08:06

Isolation and Culture of Cells from the Nephrogenic Zone of the Embryonic Mouse Kidney

Published on: April 22, 2011

Area of Science:

  • Developmental Biology
  • Molecular Biology
  • Genetics

Background:

  • Kidney development involves intricate cell type integration into epithelial structures.
  • Transcription factors and signaling pathways are known regulators of kidney development.
  • MicroRNAs (miRNAs) represent a newly identified class of regulatory molecules.

Purpose of the Study:

  • To explore the role of miRNAs in kidney development and function.
  • To understand how miRNAs interact with the transcriptional network in the kidney.
  • To investigate the potential of miRNAs in maintaining kidney function during homeostasis and injury.

Main Methods:

  • Studies utilized the pronephric kidney of Xenopus and the metanephric kidney of mouse.
  • Analysis focused on miRNA-mediated regulation of mRNA stability and translation efficiency.
  • Investigated the interplay between miRNAs and transcriptional networks.

Main Results:

  • miRNAs are crucial for regulating mRNA stability and translation efficiency in kidney development.
  • The interplay between miRNAs and transcriptional networks provides system plasticity and robustness.
  • miRNAs are essential for both early kidney development and later life function.

Conclusions:

  • miRNAs play a vital role in kidney development and homeostasis.
  • miRNA-mediated gene regulation is critical for kidney function and resilience.
  • miRNAs offer potential therapeutic targets for modulating kidney function during injury.