Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Neuroplasticity01:01

Neuroplasticity

Neuroplasticity reflects the brain's remarkable capacity to adapt and evolve, responding dynamically to learning, experiences, or injury by reorganizing its neural circuitry. This reorganization involves creating new neural connections and refining old ones through a series of biological processes that contribute to the brain's lifelong development and adaptability.
Plasticity00:58

Plasticity

Plasticity is the property where an object loses its elasticity and undergoes irreversible deformation, even after the deformation forces are eliminated. If a material deforms irreversibly without increasing stress or load, then this is called ideal plasticity. For example, when a force is applied to an aluminum rod, it changes its shape, but it does not return to its original shape once the force is removed. Plastic deformation or ductility is thus a permanent deformation or change in the...
Hierarchy of Motor Control01:18

Hierarchy of Motor Control

The hierarchy of motor control refers to the different levels of organization and processing involved in controlling movement in the body. These levels range from higher cortical areas involved in planning and decision-making to lower spinal cord reflexes that respond automatically to external stimuli.
Direct Motor Pathways01:11

Direct Motor Pathways

The direct motor pathways, also known as the pyramidal tracts, are a group of neural pathways that originate in the brain and descend through the spinal cord. They control the voluntary movement of the body. There are two major direct motor pathways: the corticospinal and the corticobulbar tracts.
The corticospinal tract is responsible for the voluntary movement of the limbs and trunk. It originates in the cerebral cortex of the brain and descends through the cerebrum's internal capsule and the...
Long-term Potentiation01:25

Long-term Potentiation

Long-term potentiation, or LTP, is one of the ways by which synaptic plasticity—changes in the strength of chemical synapses—can occur in the brain. LTP is the process of synaptic strengthening that occurs over time between pre and postsynaptic neuronal connections. The synaptic strengthening of LTP works in opposition to the synaptic weakening of long-term depression (LTD) and together are the main mechanisms that underlie learning and memory.
Hebbian LTP
LTP can occur when presynaptic neurons...
Plastic Deformations01:19

Plastic Deformations

Plastic deformation represents a fundamental concept in materials science, which explains the irreversible change in the shape of a material when it experiences stress beyond its elastic capability. This phenomenon is important in structural engineering, especially in designing and analyzing cantilever beams—structures that are securely fixed at one end and bear loads at the opposite end. When these beams are subjected to loads within their elastic range, they will return to their original...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

From inhibition to excitation and why: The role of temporal urgency in modulating corticospinal activity.

Biological psychology·2026
Same author

Mark Hallett (1943-2025): A pioneer in brain stimulation.

Brain stimulation·2025
Same author

Defining the Rhythm: Developing a New Method to Describe Tremor and Myoclonus.

Movement disorders : official journal of the Movement Disorder Society·2025
Same author

Distinct impacts of sodium channel blockers on the strength-duration properties of human motor cortex neurons.

Epilepsia·2025
Same author

Calcium-dependent nonlinearity describes the after-effects of different patterns of theta-burst TMS.

Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology·2025
Same author

Fluoxetine does not influence response to continuous theta burst stimulation in human motor cortex.

Neuropsychopharmacology reports·2024
Same journal

Navigating support pathways for children with Developmental Language Disorder in Chile: caregivers' perspectives across health and education services.

Folia phoniatrica et logopaedica : official organ of the International Association of Logopedics and Phoniatrics (IALP)·2026
Same journal

The topography of disfluency in spoken language: a scoping review.

Folia phoniatrica et logopaedica : official organ of the International Association of Logopedics and Phoniatrics (IALP)·2026
Same journal

Erratum.

Folia phoniatrica et logopaedica : official organ of the International Association of Logopedics and Phoniatrics (IALP)·2026
Same journal

Validation and Reliability of Arabic Brief Version of the Unhelpful Thoughts and Beliefs About Stuttering (UTBAS-6) Scales.

Folia phoniatrica et logopaedica : official organ of the International Association of Logopedics and Phoniatrics (IALP)·2026
Same journal

Contemporary clinical conversations about stuttering: What does childhood bilingualism mean to clinicians?

Folia phoniatrica et logopaedica : official organ of the International Association of Logopedics and Phoniatrics (IALP)·2026
Same journal

Comparing Speech Therapy Service Delivery Models in Iranian Primary Schools: A Double-Blind Randomized Controlled Study.

Folia phoniatrica et logopaedica : official organ of the International Association of Logopedics and Phoniatrics (IALP)·2026
See all related articles

Related Experiment Video

Updated: Jun 13, 2026

Study Motor Skill Learning by Single-pellet Reaching Tasks in Mice
06:04

Study Motor Skill Learning by Single-pellet Reaching Tasks in Mice

Published on: March 4, 2014

Plasticity in the human motor system.

John C Rothwell1

  • 1Institute of Neurology, University College London, London, UK. j.rothwell @ ion.ucl.ac.uk

Folia Phoniatrica Et Logopaedica : Official Organ of the International Association of Logopedics and Phoniatrics (IALP)
|May 13, 2010
PubMed
Summary
This summary is machine-generated.

Neurostimulation modifies brain plasticity to aid motor function recovery after stroke. Non-invasive techniques like transcranial magnetic stimulation show promise for enhancing rehabilitation outcomes in patients.

More Related Videos

Slice Patch Clamp Technique for Analyzing Learning-Induced Plasticity
11:56

Slice Patch Clamp Technique for Analyzing Learning-Induced Plasticity

Published on: November 11, 2017

Measuring and Manipulating Functionally Specific Neural Pathways in the Human Motor System with Transcranial Magnetic Stimulation
09:52

Measuring and Manipulating Functionally Specific Neural Pathways in the Human Motor System with Transcranial Magnetic Stimulation

Published on: February 23, 2020

Related Experiment Videos

Last Updated: Jun 13, 2026

Study Motor Skill Learning by Single-pellet Reaching Tasks in Mice
06:04

Study Motor Skill Learning by Single-pellet Reaching Tasks in Mice

Published on: March 4, 2014

Slice Patch Clamp Technique for Analyzing Learning-Induced Plasticity
11:56

Slice Patch Clamp Technique for Analyzing Learning-Induced Plasticity

Published on: November 11, 2017

Measuring and Manipulating Functionally Specific Neural Pathways in the Human Motor System with Transcranial Magnetic Stimulation
09:52

Measuring and Manipulating Functionally Specific Neural Pathways in the Human Motor System with Transcranial Magnetic Stimulation

Published on: February 23, 2020

Area of Science:

  • Neuroscience
  • Rehabilitation Medicine
  • Neuromodulation

Background:

  • Synaptic plasticity, the ability of synapses to strengthen or weaken over time, is crucial for learning and functional recovery after brain injury.
  • Non-invasive brain stimulation techniques, including transcranial magnetic stimulation (TMS) and transcranial direct current stimulation (tDCS), offer potential methods to study and modulate these plastic changes.
  • Understanding how these stimulation methods impact synaptic plasticity is key to developing effective therapeutic strategies.

Purpose of the Study:

  • To investigate the potential of non-invasive brain stimulation to enhance synaptic plasticity.
  • To explore whether modulating synaptic plasticity through neurostimulation can improve motor function recovery in stroke patients.
  • To lay the groundwork for future clinical trials assessing neurostimulation for stroke rehabilitation.

Main Methods:

  • Utilizing non-invasive brain stimulation techniques such as transcranial magnetic stimulation (TMS) and transcranial direct current stimulation (tDCS).
  • Studying the effects of these stimulation methods on synaptic plasticity in the adult brain.
  • Initiating preliminary studies to assess functional recovery, specifically motor function, in post-stroke patients undergoing neurostimulation.

Main Results:

  • Synaptic plasticity is demonstrably altered by learning and central nervous system damage.
  • Non-invasive brain stimulation methods (TMS, tDCS) can be used to study and potentially manipulate brain plasticity.
  • Early research indicates that neurostimulation-induced modification of synaptic plasticity may improve motor function recovery in stroke survivors.

Conclusions:

  • Non-invasive brain stimulation presents a promising avenue for therapeutic interventions in neurological recovery.
  • Targeting synaptic plasticity with neurostimulation could be a viable strategy to enhance motor rehabilitation post-stroke.
  • Further research and clinical trials are warranted to optimize and validate these neurostimulation techniques for stroke recovery.