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Elevated creatine phosphokinase and creatine phosphokinase-MB in acute laryngitis
1Department of Medicine A, Hadassah University Hospital, Jerusalem, Israel.
The Keio Journal of Medicine
|March 1, 1991
Summary
Elevated creatine phosphokinase (CPK) and CPK-MB levels were noted in a patient with acute laryngitis. These enzyme abnormalities were not due to acute myocardial infarction, prompting discussion of alternative mechanisms.
Area of Science:
- Biochemistry
- Clinical Medicine
- Cardiology
Background:
- Hypothyroidism management with L-thyroxine is common in older adults.
- Thyroid-stimulating hormone (TSH) and triiodothyronine (T3) levels are key indicators of thyroid function.
- Elevated creatine phosphokinase (CPK) can indicate muscle damage or cardiac events.
Observation:
- A 66-year-old female presented with acute laryngitis.
- Significantly elevated serum creatine phosphokinase (CPK) and creatine phosphokinase-MB (CPK-MB) levels were detected.
- The patient had a 10-year history of hypothyroidism treated with L-thyroxine, with normal T3 and TSH levels.
Findings:
- Repeated electrocardiogram (EKG) findings ruled out acute myocardial infarction.
- The observed CPK and CPK-MB elevations were attributed to a condition other than acute cardiac injury.
- The study explored potential mechanisms for this enzyme abnormality in the context of laryngitis.
Implications:
- This case highlights the importance of considering non-cardiac causes for elevated CPK and CPK-MB.
- Understanding these alternative mechanisms is crucial for accurate diagnosis and avoiding unnecessary cardiac interventions.
- Further research may elucidate the specific pathways leading to enzyme elevation in inflammatory conditions like laryngitis.