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Related Concept Videos

Skin Cancer01:30

Skin Cancer

Skin cancer is a type of cancer that occurs when there is an abnormal growth of skin cells, usually triggered by damage to the DNA within the skin cells. It is primarily caused by exposure to ultraviolet (UV) radiation from the sun or artificial sources like tanning beds. Skin cancer is the most common type of cancer worldwide, and its incidence continues to rise.
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Secondary Lymphoid Organs

Secondary organs, including lymph nodes, the spleen, and mucosa-associated lymphoid tissue (MALT), work harmoniously to protect us from disease and infection.
The spleen is a vital organ in the lymphatic system, nestled in the upper left side of the abdomen. It is composed of two primary regions: the red pulp and the white pulp, each having distinct functions. The red pulp performs a significant role in blood filtration. It efficiently purges the blood of old or damaged red blood cells and...
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Primary Lymphoid Organs

Primary lymphoid organs are pivotal in the formation, development, and maturation of lymphocytes, the white blood cells that serve as the backbone of our immune system. This crucial function underscores their fundamental role in maintaining our overall health and immunity. The two primary lymphoid organs of prime importance are the red bone marrow and the thymus.
The red bone marrow is a soft, spongy tissue nestled in the interior of long bones such as the humerus and femur. It is the site...
Skin Diseases and Disorders01:23

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Skin is the first line of defense and encounters a variety of microbes. Some pathogenic strains are often the cause of a broad range of infections of the skin and other body systems. These conditions can affect people of all ages and may have different causes, including genetic factors, infections, autoimmune reactions, environmental factors, and lifestyle choices.
Gram-positive Staphylococcus spp. and Streptococcus spp. are responsible for many of the most common skin infections. However, many...

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Tumor Engraftment in a Xenograft Mouse Model of Human Mantle Cell Lymphoma
10:52

Tumor Engraftment in a Xenograft Mouse Model of Human Mantle Cell Lymphoma

Published on: March 30, 2018

Cutaneous involvement with marginal zone lymphoma.

Pedram Gerami1, Scott C Wickless, Christiane Querfeld

  • 1Department of Dermatology, Northwestern University Feinberg School of Medicine, Chicago, Illinois 60611, USA. pgerami@nmff.org

Journal of the American Academy of Dermatology
|May 14, 2010
PubMed
Summary
This summary is machine-generated.

Distinguishing primary cutaneous marginal zone lymphoma (PCMZL) from secondary cutaneous MZL (SCMZL) is crucial. While histopathology is similar, SCMZL typically presents in older patients with head/neck lesions, unlike PCMZL.

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Area of Science:

  • Dermatology
  • Oncology
  • Pathology

Background:

  • Cutaneous marginal zone lymphoma (MZL) can be primary or secondary to non-cutaneous MZL.
  • Differentiating primary cutaneous MZL (PCMZL) from secondary cutaneous MZL (SCMZL) is critical for patient prognosis and treatment.
  • This distinction impacts clinical management strategies.

Purpose of the Study:

  • To describe the clinical and histologic features of secondary cutaneous MZL (SCMZL) cases.
  • To compare SCMZL cases with a cohort of primary cutaneous MZL (PCMZL) cases.
  • To identify distinctive features of SCMZL.

Main Methods:

  • Retrospective review of 30 PCMZL and 4 SCMZL cases from cutaneous lymphoma and dermatopathology databases.
  • Analysis of clinical, histologic, laboratory, and radiologic findings, disease course, treatment response, and follow-up.
  • All cases were reviewed by three dermatopathologists.

Main Results:

  • Histopathological and immunohistochemical features of SCMZL were indistinguishable from PCMZL.
  • SCMZL presented in an older patient population compared to PCMZL.
  • SCMZL lesions predominantly involved the head/neck area in 3 of 4 cases.

Conclusions:

  • Histologic and immunophenotypic features of skin lesions in SCMZL and PCMZL are often indistinguishable.
  • Clinical presentation may differ: SCMZL favors older patients and the head/neck, while PCMZL affects younger patients and favors the trunk/extremities.
  • Given potential overlap, systemic evaluation is recommended for all patients with cutaneous MZL.