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Updated: Jul 2, 2026

A Nonviral Approach to Generate Transient Chimeric Antigen Receptor T Cells Using mRNA for Cancer Immunotherapy
Published on: February 21, 2025
Genomic features of clonal hematopoiesis-associated genes in primary and CAR T-cell-related secondary T-cell
Jonathan J Park1, Zachary M Avigan2, Matthew B Dong3
1Department of Dermatology, Northwestern University Feinberg School of Medicine, Chicago, IL.
Abstract:
Secondary T-cell leukemias and lymphomas (TCLs) manifesting after chimeric antigen receptor (CAR) T-cell therapy represent an emerging concern, but their pathogenesis remains poorly understood. Risk factors are multifactorial and potentially include previous exposure to anticancer treatments, insertional mutagenesis, latent oncogenic mutations, and clonal hematopoiesis (CH). In this study, the molecular features of CAR T-cell-associated secondary TCLs are analyzed and contrasted with those of primary TCLs. Our study also examines the role of CH and its interplay with somatic mutations that are associated with TCL pathogenesis, with implications for patient risk stratification, monitoring, and treatment.
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