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Allergic Drug Reactions

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Allergic reactions related to drugs are hypersensitivity responses driven by the immune system and bear no connection to the drug's therapeutic action. While drugs in isolation do not trigger an immune response, they can interact with endogenous proteins to form antigens. These antigens stimulate lymphocytes to produce antibodies. IgE-type antibodies attach themselves to mast cells. Upon subsequent exposure to the same stimulus, the antigen-antibody interaction is initiated, unleashing numerous...

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Related Experiment Video

Updated: Jun 13, 2026

Humanized Mediator Release Assay as a Read-Out for Allergen Potency

Humanized Mediator Release Assay as a Read-Out for Allergen Potency

Published on: June 29, 2021

IgE-mediated food allergy.

Karen H Calhoun¹, Minka L Schofield

¹Department of Otolaryngology - Head and Neck Surgery, Ohio State University Medical Center, Columbus, Ohio 43212, USA. Karen.Calhoun@osumc.edu

Current Opinion in Otolaryngology & Head and Neck Surgery

|May 14, 2010

Summary

IgE-mediated food allergy, an increasing atopic disease, involves a failure of oral tolerance. Current management focuses on avoidance and epinephrine, with immunotherapy showing promise for treatment.

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Area of Science:

Immunology
Allergy Research

Background:

Increasing incidence of immunoglobulin E (IgE)-mediated food allergy.
Food allergy is characterized by a failure to achieve oral tolerance, with an imbalance in Th2 and T-regulatory cell responses.

Purpose of the Study:

To review the current understanding and management of IgE-mediated food allergy.
To highlight recent findings and future research directions in food allergy.

Main Methods:

Diagnosis relies on the gold standard double-blind, placebo-controlled food challenge.
Review of evidence regarding prevention strategies, including breastfeeding and dietary recommendations.

Main Results:

Breastfeeding shows some evidence for preventing atopic diseases, but delayed food introduction or maternal dietary restrictions are not supported.
There is no cure for food allergies; management involves strict avoidance and self-injectable epinephrine for severe reactions.
Oral immunotherapy (OIT) and sublingual immunotherapy (SLIT) are emerging as promising therapeutic options.

Conclusions:

The mechanisms underlying IgE-mediated food allergy are increasingly understood.
Further research is crucial for developing effective prevention and treatment strategies for food allergies.