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Release of (14C)5-hydroxytryptamine from human platelets by red wine
J Jarman1, V Glover, M Sandler
1Department of Chemical Pathology, Queen Charlotte's and Chelsea Hospital, London, UK.
Life Sciences
|January 1, 1991
Summary
Red wine consumption triggers the release of serotonin (5-HT) from platelets, a reaction not seen with white wines or beers. This serotonin release may explain how red wine provokes migraines in sensitive individuals.
Area of Science:
- Biochemistry
- Neuroscience
- Pharmacology
Background:
- Migraine attacks are associated with the release of serotonin (5-HT).
- Red wine is a known trigger for migraine episodes in susceptible individuals.
- The precise mechanism by which red wine provokes migraines is not fully understood.
Purpose of the Study:
- To investigate the effect of red wine on serotonin release from platelets.
- To explore a potential mechanism for red wine-induced migraines.
Main Methods:
- Platelets were preloaded with radiolabeled serotonin ([14C]5-HT).
- The effect of red wine (1/50 dilution) on serotonin release was measured.
- White wines and beers were tested for comparison.
Main Results:
- Red wine significantly induced the release of [14C]5-HT from platelets.
- No significant serotonin release was observed with tested white wines or beers.
Conclusions:
- Red wine's ability to release serotonin from platelets may be a key factor in its migraine-provoking effect.
- This serotonin release, potentially from central stores, offers a plausible mechanism for red wine-induced migraines.