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Related Experiment Video

Updated: Jun 13, 2026

3D-Neuronavigation In Vivo Through a Patient's Brain During a Spontaneous Migraine Headache
10:39

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Published on: June 2, 2014

Chronotypes in menstrual migraine: a case-control study.

Sabina Cevoli1, M Nicodemo, D Grimaldi

  • 1Department of Neurological Sciences, University of Bologna Medical School, Via U. Foscolo 7, 40123, Bologna, Italy. sabina.cevoli@unibo.it

Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology
|May 14, 2010
PubMed
Summary
This summary is machine-generated.

This study investigated chronotypes in menstrual migraine patients, finding no significant difference in circadian preferences compared to healthy women. The research did not confirm a link between migraine and specific morning or evening tendencies.

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Area of Science:

  • Neurology
  • Chronobiology
  • Sleep Medicine

Background:

  • Migraine attacks exhibit cyclical patterns, suggesting chronobiological and hypothalamic involvement.
  • Menstrual migraine, a subtype, recurs cyclically, prompting investigation into circadian rhythms.

Purpose of the Study:

  • To evaluate chronotypes in patients diagnosed with menstrual migraine.
  • To compare the circadian preferences of menstrual migraineurs with age-matched healthy women.

Main Methods:

  • Utilized the Italian version of the Morningness-Eveningness Questionnaire.
  • Recruited 93 patients with ICHD-II diagnosis of pure menstrual migraine and menstrually-related migraine.
  • Compared participants to 85 age-matched healthy female controls.

Main Results:

  • No significant differences were observed in chronotype distribution between menstrual migraine patients and healthy controls.
  • The study did not find a confirmed morning or evening preference in migraineurs, contrary to some previous reports.

Conclusions:

  • Chronotype does not appear to be a differentiating factor in menstrual migraine patients compared to the general population.
  • Further research is needed to fully understand the chronobiological underpinnings of migraine periodicity.