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Updated: Jun 13, 2026

Calcification of Vascular Smooth Muscle Cells and Imaging of Aortic Calcification and Inflammation
Published on: May 31, 2016
Severe aphthous stomatitis associated with oral calcineurin and mTOR inhibitors
Nancy Habib1, Cristina Salaro, Khalid Al-Ghaithi
1Montefiore Medical Center, Albert Einstein College of Medicine, Bronx, NY 10467, USA.
Background:
Aphthous stomatitis, a common mucocutaneous disorder, is a well accepted complication of sirolimus therapy. This association has been reported less frequently with tacrolimus.
Case:
We present an 11-year old male with Budd-Chiari syndrome who experienced profound worsening of chronic aphthous ulcers after immunosuppressive therapy was changed from tacrolimus to sirolimus.
Conclusion:
Since these drugs are used widely in the pediatric transplantation population, this report serves to heighten awareness of this debilitating phenomenon, and to stress the importance of exercising caution when sirolimus and tacrolimus are administered in combination to pediatric patients.
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