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Updated: Jun 13, 2026

Development of an IFN-γ ELISpot Assay to Assess Varicella-Zoster Virus-specific Cell-mediated Immunity Following Umbilical Cord Blood Transplantation
Published on: July 9, 2014
Herpes viruses in transplant recipients: HSV, VZV, human herpes viruses, and EBV
1Division of Infectious Diseases, Hospital of the University of Pennsylvania, 3rd Floor Silverstein Pavilion, Suite E, 3400 Spruce Street, Philadelphia, PA 19104, USA. shileyk@uphs.upenn.edu
Abstract:
The herpes viruses are responsible for a wide range of diseases in patients following transplant, resulting from direct viral effects and indirect effects, including tumor promotion. Effective treatments and prophylaxis exist for the neurotropic herpes viruses HSV-1, HSV-2, varicella zoster virus, and possibly HHV-6. Antivirals seem to be less effective at prevention of the tumor-promoting effects of Epstein-Barr virus and HHV-8. Reduction in immunosuppression is the cornerstone to treatment of many diseases associated with herpes virus infections.
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