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Related Concept Videos

Hedgehog Signaling Pathway02:33

Hedgehog Signaling Pathway

The Hedgehog gene (Hh) was first discovered due to its control of the growth of disorganized, hair-like bristles phenotype in Drosophila, much like hedgehog spines. Hh plays a crucial role in the development of organs and the maintenance of homeostasis in both invertebrates and vertebrates. However, while Drosophila has only one Hh protein, mammals have multiple functional Hedgehog proteins - Sonic (Shh), Desert (Dhh), and Indian Hedgehog (Ihh). All of these homologous proteins have adapted to...
Hedgehog Signaling Pathway02:33

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Updated: Jun 13, 2026

Organotypic Slice Cultures of Embryonic Ventral Midbrain: A System to Study Dopaminergic Neuronal Development in vitro
07:33

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Published on: January 31, 2012

Sonic hedgehog functions through dynamic changes in temporal competence in the developing forebrain.

Vitor H Sousa1, Gord Fishell

  • 1Smilow Neuroscience Program, Department of Cell Biology, New York University Langone Medical Center, New York, NY 10016, USA.

Current Opinion in Genetics & Development
|May 15, 2010
PubMed
Summary
This summary is machine-generated.

Temporal responses to Sonic hedgehog (Shh) signaling change during nervous system development. These changes in progenitor competence are driven by transcriptional mechanisms integrating multiple signaling pathways.

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Last Updated: Jun 13, 2026

Organotypic Slice Cultures of Embryonic Ventral Midbrain: A System to Study Dopaminergic Neuronal Development in vitro
07:33

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Published on: January 31, 2012

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Isolation and Cultivation of Neural Progenitors Followed by Chromatin-Immunoprecipitation of Histone 3 Lysine 79 Dimethylation Mark

Published on: January 26, 2018

Area of Science:

  • Developmental biology
  • Neuroscience
  • Molecular biology

Background:

  • Morphogens provide spatial information during embryonic development, controlling cell fate and tissue patterning.
  • Sonic hedgehog (Shh) signaling is crucial for patterning the developing nervous system, particularly the ventral telencephalon.
  • While downstream transcription factors are known, the intracellular machinery mediating Shh responses is less understood.

Purpose of the Study:

  • To investigate dynamic changes in temporal responses to Shh signaling in the developing ventral telencephalon.
  • To explore the role of progenitor competence in mediating these temporal response changes.
  • To identify the transcriptional mechanisms underlying developmental alterations in Shh pathway responsiveness.

Main Methods:

  • Analysis of Shh signaling dynamics in progenitor cells.
  • Investigating changes in progenitor cell competence during development.
  • Identifying transcriptional regulators integrating multiple signaling pathways.

Main Results:

  • Demonstrated dynamic changes in temporal responses to Shh in the ventral telencephalon.
  • Identified alterations in progenitor competence as the mechanism for these dynamic responses.
  • Proposed a transcriptional mechanism integrating distinct signaling pathways to modulate Shh responsiveness.

Conclusions:

  • Progenitor competence is a key factor in regulating temporal responses to morphogen signaling during development.
  • Transcriptional mechanisms play a critical role in integrating information from multiple signaling pathways to fine-tune developmental patterning.
  • Understanding these mechanisms is essential for comprehending nervous system development and potential therapeutic interventions.