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Related Concept Videos

Irritable Bowel Syndrome II: Clinical Features and Diagnostic Evaluation01:30

Irritable Bowel Syndrome II: Clinical Features and Diagnostic Evaluation

Irritable Bowel Syndrome II: Clinical Features and Diagnostic Evaluation
Irritable Bowel Syndrome (IBS) is classified into subtypes based on the predominant bowel habits as determined by the Bristol Stool Form Scale (BSFS). The subtypes are:
Irritable Bowel Syndrome I: Introduction01:17

Irritable Bowel Syndrome I: Introduction

Irritable Bowel Syndrome (IBS) is characterized by functional disturbances in the gastrointestinal system, presenting a cluster of symptoms without evident structural or biochemical abnormalities. It primarily affects the large intestine and may cause abdominal pain, bloating, excessive gas, diarrhea, constipation, or both.
IBS is a chronic condition that can persist over a long period or recur frequently.
The pathogenesis of IBS involves a complex interplay of the following factors:
Altered...
Irritable Bowel Syndrome01:23

Irritable Bowel Syndrome

DefinitionIrritable bowel syndrome (IBS) is a functional gastrointestinal disorder characterized by recurrent combinations of abdominal pain, bloating, diarrhea, or constipation.Pathophysiology of irritable bowel syndromeIts pathophysiology is multifactorial, involving disturbances in motility, sensory processing, microbial balance, barrier integrity, and gut–brain communication. These mechanisms interact to produce symptoms that vary across IBS subtypes.Altered Motility PatternsDisordered...
Serum Laboratory Studies, Stool Test, Breath Test01:30

Serum Laboratory Studies, Stool Test, Breath Test

Gastrointestinal (GI) diagnostic studies are pivotal in confirming, ruling out, diagnosing, or staging various diseases, including cancers. Following diagnosis, allocating time for discussions with the patient and providing informational resources is crucial. Diagnostic assessments of the GI tract often occur in outpatient settings like endoscopy suites or GI labs. Preparation for these tests may include dietary restrictions, fasting, liquid bowel preparations, laxatives, enemas, and the...
Inflammatory Bowel Disease III: Diagnostic Studies and Management I-Nutritional Therapy01:30

Inflammatory Bowel Disease III: Diagnostic Studies and Management I-Nutritional Therapy

Various diagnostic tests are employed in the diagnostic process for Inflammatory Bowel Disease (IBD), particularly to differentiate between Crohn's disease and ulcerative colitis.
Diagnostic studies
A colonoscopy is the definitive screening test, distinguishing ulcerative colitis from other colon diseases with similar symptoms. During a colonoscopy test, inflamed mucosa with exudate ulcerations can be observed, and biopsies are taken to determine the histologic characteristics of the colonic...
Irritable Bowel Syndrome III: Medical and Nursing Management01:30

Irritable Bowel Syndrome III: Medical and Nursing Management

Managing Irritable Bowel Syndrome (IBS) involves a multifaceted approach, including lifestyle modifications, dietary changes, and medication.

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Related Experiment Video

Updated: Jun 13, 2026

Perturbations of Circulating miRNAs in Irritable Bowel Syndrome Detected Using a Multiplexed High-throughput Gene Expression Platform
10:37

Perturbations of Circulating miRNAs in Irritable Bowel Syndrome Detected Using a Multiplexed High-throughput Gene Expression Platform

Published on: November 30, 2016

Abnormal breath testing in IBS: a meta-analysis.

Eric D Shah1, Robert J Basseri, Kelly Chong

  • 1School of Medicine, Texas Tech University Health Sciences Center, Lubbock, TX, USA.

Digestive Diseases and Sciences
|May 15, 2010
PubMed
Summary
This summary is machine-generated.

Breath testing is a valid tool for identifying abnormal intestinal bacteria in irritable bowel syndrome (IBS) patients. This systematic review and meta-analysis confirms abnormal breath test results in IBS compared to healthy individuals.

More Related Videos

Breath Collection from Children for Disease Biomarker Discovery
06:09

Breath Collection from Children for Disease Biomarker Discovery

Published on: February 14, 2019

Related Experiment Videos

Last Updated: Jun 13, 2026

Perturbations of Circulating miRNAs in Irritable Bowel Syndrome Detected Using a Multiplexed High-throughput Gene Expression Platform
10:37

Perturbations of Circulating miRNAs in Irritable Bowel Syndrome Detected Using a Multiplexed High-throughput Gene Expression Platform

Published on: November 30, 2016

Breath Collection from Children for Disease Biomarker Discovery
06:09

Breath Collection from Children for Disease Biomarker Discovery

Published on: February 14, 2019

Area of Science:

  • Gastroenterology
  • Microbiology
  • Diagnostic Medicine

Background:

  • Emerging evidence links enteric bacteria to irritable bowel syndrome (IBS) symptoms.
  • Small intestinal bacterial overgrowth (SIBO) was initially suspected based on abnormal lactulose breath tests.
  • Skepticism regarding breath test accuracy in humans has persisted despite some antibiotic study successes.

Purpose of the Study:

  • To systematically review and meta-analyze studies utilizing breath testing in IBS subjects.
  • To compare the prevalence of abnormal breath test results in IBS patients versus healthy controls.
  • To assess the validity of breath testing as a diagnostic tool for IBS.

Main Methods:

  • Conducted a literature search for studies involving breath testing in IBS patients.
  • Identified case-control studies for detailed paper review.
  • Applied exclusion criteria and performed meta-analysis on eligible studies.
  • Analyzed prevalence of abnormal breath tests in IBS versus matched healthy controls.

Main Results:

  • Eleven studies were included in the meta-analysis, with lactulose being the most common substrate.
  • Breath testing was significantly more abnormal in IBS subjects than healthy controls (OR=4.46).
  • Analysis of age- and sex-matched studies showed a higher abnormality rate in IBS (OR=9.64).
  • Overall sensitivity and specificity for breath testing were 43.6% and 83.6%, respectively.

Conclusions:

  • Breath test findings in IBS subjects appear to be valid.
  • While not definitively proving SIBO, abnormal fermentation patterns suggest a role for altered intestinal bacterial distribution in IBS.
  • The study supports the utility of breath testing in the context of IBS symptom evaluation.