Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Chronic Kidney Disease III: Interprofessional Care

Chronic Kidney Disease III: Interprofessional Care

Chronic kidney disease (CKD) requires collaborative and comprehensive management. CKD progresses through stages and can lead to end-stage kidney disease (ESKD) if untreated. Interprofessional collaboration and patient education are crucial, enabling patients to manage their health and improve their quality of life.Diagnostic approach for chronic kidney diseaseThe diagnosis of CKD primarily focuses on the glomerular filtration rate (GFR), which assesses kidney function by measuring how well...

Chronic Kidney Disease IV: Nursing Management

Chronic Kidney Disease IV: Nursing Management

Nursing management is essential for preventing complications, maintaining stability, and improving patients' quality of life in chronic kidney disease (CKD). By using a structured approach, nurses help slow CKD progression and support effective patient care.1. Comprehensive patient assessmentEffective management begins with nurses reviewing the patient’s medical history, and identifying key risk factors like diabetes, hypertension, and nephrotoxic drug use. Nurses assess signs of fluid...

Drug Dosing in Renal Diseases: Estimation of Glomerular Filtration Rate Based on Serum Creatinine Concentration

Drug Dosing in Renal Diseases: Estimation of Glomerular Filtration Rate Based on Serum Creatinine Concentration

Glomerular filtration rate (GFR) can be estimated from serum creatinine using the modification of diet in renal disease (MDRD) formula or the chronic kidney disease–epidemiology collaboration (CKD–EPI) equation. Both methods are widely used in clinical practice to assess kidney function and guide treatment decisions.The MDRD equation does not require weight or height measurements and is normalized to the body surface area of 1.73 m², considered the average adult surface area. This equation is...

Nephrotic Syndrome II : Assessment and Medical Management

Nephrotic Syndrome II : Assessment and Medical Management

IntroductionNephrotic syndrome is a kidney disorder marked by excessive protein loss in the urine, leading to various systemic complications. This condition often results from damage to the glomeruli—the kidney's filtering units—causing proteinuria, low blood protein levels, and fluid retention. Understanding the assessment, diagnosis, and management of nephrotic syndrome is essential for effective treatment and prevention of further kidney damage.AssessmentPatient History: Document any history...

Drug Dosing in Renal Diseases: Dose Adjustments Based on Drug Clearance and Elimination Rate Constant

Drug Dosing in Renal Diseases: Dose Adjustments Based on Drug Clearance and Elimination Rate Constant

In patients with renal disease, dosage adjustments are necessary to maintain therapeutic plasma drug concentrations and prevent toxicity or subtherapeutic exposure. Renal impairment alters drug pharmacokinetics, especially in conditions like uremia, where changes such as prolonged elimination half-life and altered apparent volume of distribution can significantly affect drug disposition. These changes require careful modification of the dosing regimen to achieve the desired clinical...

Physiology of the Genitourinary System I: Renal Blood Flow and Glomerular Filtration

Physiology of the Genitourinary System I: Renal Blood Flow and Glomerular Filtration

The kidneys are vital organs responsible for regulating blood filtration, waste excretion, and fluid balance, all of which are crucial for maintaining homeostasis. Renal physiology examines renal blood flow, glomerular filtration, and urine formation, ensuring the body’s internal environment remains stable.Renal Blood FlowThe kidneys receive about 20-25% of the cardiac output, typically around 1200 mL of blood per minute in an average adult. Blood flows into the kidneys through the renal...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

From challenge to innovation: a narrative review on innovation in nephrology and hemodialysis randomized trials.

Journal of nephrology·2026

Same author

The Association Between Pulmonary Hypertension, End-Stage Kidney Disease, and Death: An Analysis of the Chronic Renal Insufficiency Cohort Study (CRIC).

Kidney medicine·2026

Same author

Primary prevention of chronic kidney disease in type 2 diabetes mellitus with sodium-glucose cotransporter 2 inhibitors.

Current opinion in nephrology and hypertension·2026

Same author

Safety and Synergy of Finerenone and Empagliflozin in Lowering Blood Pressure.

Hypertension (Dallas, Tex. : 1979)·2026

Same author

Hemodiafiltration beyond the CONVINCE trial.

Clinical kidney journal·2026

Same author

Choice and impact of EQ-5D-5L value set in cost-utility analyses alongside multinational trials: Insights from PREFERABLE-EFFECT and CONVINCE.

PloS one·2026

Search research articles

Related Experiment Video

Updated: Jun 13, 2026

5/6 Nephrectomy Using Sharp Bipolectomy Via Midline Laparotomy in Rats

5/6 Nephrectomy Using Sharp Bipolectomy Via Midline Laparotomy in Rats

Published on: April 4, 2025

How to read a nephrology systematic review.

Suetonia C Palmer¹, Sankar D Navaneethan, Giovanni F M Strippoli

¹Department of Medicine, University of Otago, Christchurch, New Zealand. suetoniapalmer@clear.net.nz

Nephrology (Carlton, Vic.)

|May 18, 2010

Summary

Systematic reviews offer reliable evidence for clinical decisions in nephrology. They rigorously summarize primary studies, providing more precise and comprehensive conclusions than individual research.

Related Experiment Videos

Last Updated: Jun 13, 2026

5/6 Nephrectomy Using Sharp Bipolectomy Via Midline Laparotomy in Rats

5/6 Nephrectomy Using Sharp Bipolectomy Via Midline Laparotomy in Rats

Published on: April 4, 2025

Area of Science:

Nephrology
Clinical Research Methodology
Evidence-Based Medicine

Background:

Clinical decision-making in nephrology relies on accurate evidence.
Individual studies may lack comprehensive or precise findings.
Systematic reviews offer a superior method for evidence synthesis.

Purpose of the Study:

To describe the essential components of systematic reviews and meta-analyses.
To outline critical features for assessing the validity of systematic reviews.
To guide the application of systematic review outcomes in clinical nephrology.

Main Methods:

Summarizing all primary studies evaluating a specific clinical question.
Employing rigorous and pre-specified methodologies.
Focusing on the synthesis and critical appraisal of research.

Main Results:

Systematic reviews provide more reliable, precise, and comprehensive conclusions.
Key components of systematic reviews and meta-analyses are detailed.
Features for evaluating systematic review accuracy and validity are presented.

Conclusions:

Systematic reviews are the optimal method for summarizing evidence in nephrology.
Understanding systematic review methodology enhances clinical decision-making.
Critical appraisal of systematic reviews ensures reliable application of findings.