Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Effect of Hepatic Disease on Pharmacokinetics: Pathophysiologic Assessment and Liver Function Test01:22

Effect of Hepatic Disease on Pharmacokinetics: Pathophysiologic Assessment and Liver Function Test

271
In clinical practice, the direct measurement of hepatic blood flow to evaluate liver function presents significant challenges due to the intricate and specialized nature of the necessary techniques. Consequently, healthcare professionals often rely on empirical estimates derived from thorough patient examinations and liver function tests to gauge liver health. Among the tools at their disposal, the Child–Pugh and MELD scoring systems stand out for their ability to categorize and assess...
271
Hepatic Encephalopathy01:29

Hepatic Encephalopathy

53
DefinitionHepatic encephalopathy is a reversible neurologic syndrome that results from advanced liver dysfunction or portosystemic shunting. It leads to disturbances in cognition, behavior, and motor function due to the brain’s exposure to gut-derived toxins that the liver fails to detoxify.EtiologyThis condition develops either in the setting of acute fulminant hepatitis or progressively during chronic liver disease, such as cirrhosis and portal hypertension. Portosystemic...
53

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Towards point-of-care tests for protein detection at the attomolar level via disposable pollen-based nanoplasmonic probes grafted with polymer-based receptors.

Biomedical optics express·2026
Same author

Toscana Virus Diagnosis via a Point-of-Care Tool Based on Disposable Optical Fiber Biosensors.

Analytical chemistry·2026
Same author

Modified Plastic Optical Fibers Combined with Molecularly Imprinted Polymers and Gold Nanorods for Furfural Detection at the Picomolar Level via Plasmonic Phenomena.

Polymers·2026
Same author

Towards Haemoglobin Detection in Finger-Prick Sampling via Low-Cost Disposable Sensor Chips Based on eMIPs on Plasmonic Optical Fiber Probes.

Nanomaterials (Basel, Switzerland)·2026
Same author

Towards point-of-care tests: Comparative study of different antibody densities for plasmonic surfaces to achieve custom IL-18 biosensors.

Colloids and surfaces. B, Biointerfaces·2026
Same author

Prevention of Portal Hypertension Complications Beyond Primary TIPS Indication Is Independent of Endoprosthesis Under-Dilation.

Liver international : official journal of the International Association for the Study of the Liver·2026

Related Experiment Video

Updated: May 1, 2026

Online Transcranial Magnetic Stimulation Protocol for Measuring Cortical Physiology Associated with Response Inhibition
08:55

Online Transcranial Magnetic Stimulation Protocol for Measuring Cortical Physiology Associated with Response Inhibition

Published on: February 8, 2018

9.1K

Improving the inhibitory control task to detect minimal hepatic encephalopathy.

Piero Amodio1, Lorenzo Ridola, Sami Schiff

  • 1Department of Clinical and Experimental Medicine, University of Padua, Padua, Italy. piero.amodio@unipd.it

Gastroenterology
|May 18, 2010
PubMed
Summary

The inhibitory control task (ICT) is not effective for diagnosing minimal hepatic encephalopathy (MHE) alone. Adjusting ICT lures by target accuracy improves MHE detection, but target accuracy alone is more effective.

More Related Videos

Disruption of Frontal Lobe Neural Synchrony During Cognitive Control by Alcohol Intoxication
09:26

Disruption of Frontal Lobe Neural Synchrony During Cognitive Control by Alcohol Intoxication

Published on: February 6, 2019

17.3K
Dual-Task Stroop Paradigm for Detecting Cognitive Deficits in High-Functioning Stroke Patients
07:42

Dual-Task Stroop Paradigm for Detecting Cognitive Deficits in High-Functioning Stroke Patients

Published on: December 16, 2022

3.1K

Related Experiment Videos

Last Updated: May 1, 2026

Online Transcranial Magnetic Stimulation Protocol for Measuring Cortical Physiology Associated with Response Inhibition
08:55

Online Transcranial Magnetic Stimulation Protocol for Measuring Cortical Physiology Associated with Response Inhibition

Published on: February 8, 2018

9.1K
Disruption of Frontal Lobe Neural Synchrony During Cognitive Control by Alcohol Intoxication
09:26

Disruption of Frontal Lobe Neural Synchrony During Cognitive Control by Alcohol Intoxication

Published on: February 6, 2019

17.3K
Dual-Task Stroop Paradigm for Detecting Cognitive Deficits in High-Functioning Stroke Patients
07:42

Dual-Task Stroop Paradigm for Detecting Cognitive Deficits in High-Functioning Stroke Patients

Published on: December 16, 2022

3.1K

Area of Science:

  • Neuroscience
  • Hepatology
  • Cognitive Psychology

Background:

  • Minimal hepatic encephalopathy (MHE) diagnosis relies on various tests.
  • The inhibitory control task (ICT) quantifies noninhibited responses (lures) for MHE diagnosis.
  • Efficacy of ICT requires comparison with established diagnostic standards.

Purpose of the Study:

  • To assess the diagnostic efficacy of the inhibitory control task (ICT) for minimal hepatic encephalopathy (MHE).
  • To compare ICT performance against recommended diagnostic standards like psychometric hepatic encephalopathy score (PHES).

Main Methods:

  • Two-center study involving patients with cirrhosis and healthy controls.
  • Inhibitory control task (ICT) administered to all participants.
  • MHE diagnosis assessed using psychometric hepatic encephalopathy score (PHES), critical flicker frequency, and spectral electroencephalogram analyses.

Main Results:

  • Patients with cirrhosis exhibited higher ICT lures and lower target accuracy than controls.
  • ICT lures did not significantly differ between patients with and without altered PHES.
  • A derived variable, 'weighted lures,' showed potential but target accuracy alone demonstrated superior diagnostic performance (AUC=0.81).

Conclusions:

  • The inhibitory control task (ICT) is not a reliable standalone diagnostic tool for MHE.
  • Adjusting ICT lures by target accuracy enhances its utility, but target accuracy itself is a more effective diagnostic variable.
  • Assessing attention (target accuracy) appears more valuable than assessing inhibition (lures) for MHE detection.