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Updated: Jun 13, 2026

Real-Time Polymerase Chain Reaction-Based Detection and Quantification of Hepatitis B Virus DNA
Published on: December 15, 2023
[Prevention of hepatitis B transmission during the delivery in Picardy (2006)]
Anne Lerat1, Alain Braillon, Dominique Capron
1CHU d'Amiens, Santé publique, 80054 Amiens cedex 1, France.
Object:
No French publication is available to assess the prevention of the hepatitis B transmission during delivery. The aim of this study was to evaluate the traceability and the compliance with the guidelines for administration of hepatitis B immune globulin (Ig) in public and private maternities of Picardy.
Method:
We obtained the files of the mothers who were likely to be HBsAg + by a query in the medico-administrative data base (PMSI). Newborns who received hepatitis B Ig were obtained by the pharmacies and the obstetrical wards's registers and a PMSI query.
Results:
Nineteen of 20 maternities participated to the study. One hundred and forty five files were identified (65 mothers HBsAg +, 75 HBsAg -, 5 unknown) and 81 hepatitis B Ig injections were rated in the file and 5 unrated. Twenty percent of the rated Ig injections (16/81) were not pertinent (new born from HbsAg - mothers). Dose complied with the guidelines (100 UI) in 85 % of cases and the schedule (within the 12 first hours after delivery) in 79 %. The traceability was present in 69 % of the files. As a whole, only 40 % (32/81) of Ig injections follow the guidelines indications (indication, recommended dose and time, traceability). A letter (for general practitioner, pediatrician or hepatologist) for follow up of the baby or/and the mother was found in 40 files out of 145.
Discussion:
The prevention of the hepatitis B transmission during the delivery must be improved through a national strategy with a multi-professional mobilisation plus a local implementation.
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