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The differences in left ventricular torsional behavior between patients with hypertrophic cardiomyopathy and

Makoto Saito1, Hideki Okayama, Toyofumi Yoshii

  • 1Division of Cardiology, Department of Integrated Medicine and Informatics, Ehime University Graduate School of Medicine, Toon, Japan.

International Journal of Cardiology
|May 18, 2010
PubMed

Insights

Patients with hypertrophic cardiomyopathy (HCM) show increased left ventricular (LV) torsion but impaired untwisting. This suggests HCM’s compensatory mechanisms for LV untwisting are insufficient compared to hypertensive heart disease (HHD).

Area of Science:

  • Cardiology
  • Cardiovascular Imaging
  • Biomedical Engineering

Background:

  • Hypertrophic cardiomyopathy (HCM) and hypertensive heart disease (HHD) are distinct conditions affecting the left ventricle (LV).
  • Understanding differences in LV twisting mechanics is crucial for diagnosis and management.

Purpose of the Study:

  • To compare left ventricular (LV) twisting dynamics between patients with HCM and HHD.
  • To elucidate the compensatory mechanisms in LV untwisting in these conditions.

Main Methods:

  • Echocardiography and 2D speckle tracking imaging were used to analyze LV twist and twisting velocity.
  • Evaluated 44 HCM patients, 35 HHD patients, and 20 controls.

Main Results:

  • HCM and HHD groups exhibited significantly greater peak LV torsion than controls.
  • The ratio of peak untwisting velocity to peak torsion was significantly reduced in HCM patients compared to HHD and controls.
  • Time to peak untwisting velocity was prolonged in HCM patients.

Conclusions:

  • Enhanced LV torsion in HCM may partially improve untwisting but does not fully compensate.
  • LV untwisting behavior is impaired in HCM compared to HHD, despite similar increases in torsion.
Abstract

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