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Ventilatory patterning in a mouse model of stroke.

Brian B Koo1, Kingman P Strohl, Carl B Gillombardo

  • 1Department of Neurology, Case Western Reserve University School of Medicine, Louis Stokes Veterans Affairs Medical Center, Cleveland, OH 44106, USA. brian.koo@uhhospitals.org

Respiratory Physiology & Neurobiology
|May 18, 2010
PubMed
Summary

Cerebral infarction, a type of stroke, can cause breathing instability. This study in mice showed that stroke leads to irregular breathing patterns, similar to Cheyne-Stokes respiration (CSR).

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Area of Science:

  • Neuroscience
  • Respiratory Physiology

Background:

  • Cheyne-Stokes respiration (CSR) is a breathing pattern with waxing and waning breath volume and frequency.
  • CSR is often observed after stroke, but the underlying mechanisms remain unclear.

Purpose of the Study:

  • To investigate if cerebral infarction (stroke) causes breathing instability.
  • To model the causal pathways of breathing pattern changes following stroke.

Main Methods:

  • Used a stroke model in A/J mice (n=7) versus sham controls (n=7).
  • Measured ventilation using whole body plethysmography.
  • Analyzed respiratory rate, tidal volume, minute ventilation, and oscillatory behaviors using computational models for complexity and information theory.

Main Results:

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  • Stroke-induced breathing showed lower respiratory rate and autocorrelation compared to sham.
  • Higher coefficient of variation for tidal volume and minute ventilation was observed post-stroke.
  • Breathing in stroke model exhibited increased mutual information, nonlinear complexity, and a waxing/waning pattern consistent with CSR.

Conclusions:

  • Cerebral infarction leads to increased ventilatory variability and nonlinear patterning.
  • The observed breathing pattern in the stroke model is consistent with Cheyne-Stokes respiration (CSR).
  • This study provides evidence for cerebral infarction as a mechanism producing breathing instability and CSR.