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Related Concept Videos

Treatment Resistant Cancers02:56

Treatment Resistant Cancers

Cancer is the second leading cause of death in the United States. A cancer cell is genetically unstable and hence can mutate faster. They can also modify their microenvironment and escape immune surveillance. The difficulties in treating cancer are further compounded by the emergence of rapid resistance to anticancer drugs. The most common ways to attain resistance in cancer cells include alteration in drug transport and metabolism, modification of drug target, elevated DNA damage response, or...
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Tissue transplantation is a significant medical procedure involving the transfer of cells, tissues, or organs from a donor to a recipient, with the primary aim of restoring lost functions. This procedure is crucial in treating a broad spectrum of diseases, including kidney diseases, liver failure, heart disease, and certain types of cancers.
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Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.

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Multimodal Bioluminescent and Positronic-emission Tomography/Computational Tomography Imaging of Multiple Myeloma Bone Marrow Xenografts in NOG Mice
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Multiple myeloma - current issues and controversies.

Shaji Kumar1

  • 1Division of Hematology, Department of Medicine, Mayo Clinic, Rochester, MN 55905, USA. kumar.shaji@mayo.edu

Cancer Treatment Reviews
|May 18, 2010
PubMed
Summary
This summary is machine-generated.

Advances in multiple myeloma treatments have significantly improved patient outcomes. Optimal use of novel therapies like thalidomide, lenalidomide, and bortezomib is debated to maximize survival and explore potential cure.

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Establishment of a Human Multiple Myeloma Xenograft Model in the Chicken to Study Tumor Growth, Invasion and Angiogenesis
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Published on: May 1, 2015

Area of Science:

  • Hematology
  • Oncology
  • Internal Medicine

Background:

  • Patient outcomes in multiple myeloma have dramatically improved over the last decade.
  • This improvement is attributed to novel therapies, high-dose therapy, and better complication management.

Purpose of the Study:

  • To interpret the current knowledge on multiple myeloma treatment.
  • To provide a perspective on current issues and controversies in managing the disease.
  • To address questions regarding the optimal use of novel therapies like thalidomide, lenalidomide, and bortezomib.

Main Methods:

  • Review and interpretation of current scientific literature.
  • Analysis of treatment outcomes and emerging therapeutic strategies.
  • Discussion of controversies surrounding treatment goals, including cure.

Main Results:

  • Novel therapeutic regimens, including thalidomide, lenalidomide, and bortezomib, have shown high response rates.
  • Significant improvements in patient survival and quality of life have been observed.
  • Debate continues regarding the ultimate goal of therapy, with the concept of cure being re-evaluated.

Conclusions:

  • The optimal sequencing and combination of novel agents require further investigation.
  • Achieving long-term remission and exploring the possibility of a cure are key future directions.
  • Continued research is essential to refine treatment strategies and maximize survival for multiple myeloma patients.