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Perfusion MRI demonstrates crossed-cerebellar diaschisis in sickle cell disease

Ruth L O'Gorman1, Ata Siddiqui, David C Alsop

  • 1Department of Neuroradiology, King's College Hospital, London, United Kingdom. ruth.ogorman@kcl.ac.uk

Pediatric Neurology
|May 18, 2010
PubMed

Insights

Arterial spin labeling (ASL) effectively visualized crossed-cerebellar diaschisis in a pediatric sickle cell patient. This noninvasive MRI technique shows promise for evaluating such conditions in children.

Area of Science:

  • Neurology
  • Radiology
  • Pediatric Imaging

Background:

  • Arterial spin labeling (ASL) is a noninvasive MRI technique for assessing blood flow.
  • Pediatric perfusion imaging requires specialized, safe, and effective methods.
  • Sickle cell disease can lead to significant cerebrovascular complications.

Observation:

  • An 8-year-old boy with sickle cell disease presented with extensive right-hemispheric cerebral infarction.
  • Crossed-cerebellar diaschisis was observed in the patient.
  • ASL perfusion MRI was utilized for imaging.

Findings:

  • ASL successfully demonstrated crossed-cerebellar diaschisis in this pediatric case.
  • The findings highlight the utility of ASL in identifying complex neurological deficits.
  • This represents the first reported case of crossed-cerebellar diaschisis visualized with ASL.

Implications:

  • ASL perfusion MRI is valuable for the clinical evaluation and follow-up of crossed-cerebellar diaschisis.
  • ASL is a suitable method for routine perfusion imaging in pediatric patients.
  • This case underscores the potential of ASL in managing pediatric neurological disorders.

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