Biological nature of Cryptosporidium sp. isolated from a cat

A small type of Cryptosporidium oocysts was isolated from a naturally infected cat and its biological nature was investigated. In cats experimentally inoculated with Cryptosporidium oocysts, long-lasting shedding of the oocysts occurred after a prepatent period of 8-10 days, and a number of peaks of oocyst count appeared at intervals of several days to a few weeks, earlier in the infection course. Cryptosporidium infection in cats is likely to pass from an acute to a chronic stage. During the chronic stage, prednisolone injection into the cats gave rise to a recurrence of proliferation of the parasite along with a marked increase in the number of oocysts shed. None of the infected cats showed clinical symptoms. Infection experiments using Cryptosporidium oocysts were unsuccessful in several species of animals such as mice, rats, guinea pigs, dogs, suckling mice and mice previously injected with prednisolone or hydrocortisone.