Peripheral neuropathy and solitary plasmacytoma

Area of Science:

• Neurology
• Oncology

Background:

• Peripheral neuropathy can present with diverse etiologies.
• Solitary plasmacytoma is a rare plasma cell neoplasm.

Observation:

• Three male patients presented with progressive sensorimotor neuropathy and elevated cerebrospinal fluid (CSF) protein.
• Initial investigations for neuropathy were negative, delaying diagnosis.

Findings:

• A solitary plasmacytoma was identified in all three patients via skeletal surveys.
• Irradiation therapy for the plasmacytoma led to substantial improvement in neurological deficits.

Implications:

• Suggests a skeletal survey for middle-aged men with obscure neuropathy and elevated CSF protein.
• Highlights the potential for significant neurological recovery through early plasmacytoma detection and treatment.