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Generation of Induced Regulatory T Cells from Primary Human Naïve and Memory T Cells
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Published on: April 16, 2012

CD4+CD25+ regulatory T-cell therapy

Shuiping Jiang1, Robert I Lechler, Giovanna Lombardi

  • 1Immunoregulation Laboratory, Department of Nephrology and Transplantation, King's College, Guy's Hospital, London SE1 9RT, UK. shuiping.jiang@kcl.ac.uk

Expert Review of Clinical Immunology
|May 19, 2010
PubMed

Naturally occurring CD4(+)CD25(+) regulatory T cells (Tregs) expressing forkhead transcript factor box P3 have been established as a key regulator for the control of autoimmunity. A growing body of experiments in animal models has provided compelling evidence that the adoptive transfer of CD4(+)CD25(+) Tregs can cure many autoimmune and allergic diseases, and appear to induce donor-specific transplantation tolerance. Thus, customer-tailored CD4(+)CD25(+) Tregs have emerged as potential reagents for adoptive cell therapy for individualized medicine. This review discusses recent advances towards that goal.

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