Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Asthma-II: Pathophysiology and Classification01:26

Asthma-II: Pathophysiology and Classification

Asthma is a prevalent chronic respiratory condition marked by inflammation and hyperresponsiveness of the airways. Its pathophysiology involves complex interactions among inflammatory pathways, immune responses, and neural mechanisms.
Additionally, environmental and genetic factors play crucial roles in determining an individual's susceptibility to asthma and the severity of their condition.
Critical processes in asthma pathophysiology include:
Asthma I: Introduction01:28

Asthma I: Introduction

Asthma is a chronic inflammatory disorder of the airways characterized by variable airflow obstruction and heightened bronchial responsiveness to a wide range of triggers. The underlying inflammation leads to airway swelling, mucus hypersecretion, and smooth muscle constriction, all of which narrow the airway lumen and impede airflow. Clinically, asthma presents with recurrent episodes of wheezing, shortness of breath, chest tightness, and coughing, symptoms that typically vary in intensity and...
Asthma: Pathogenesis and Management01:20

Asthma: Pathogenesis and Management

Asthma is a chronic pulmonary condition involving inflammation of the airways, hyper-reactivity, and reversible obstruction of the airways. This condition can significantly impact a person's quality of life, making breathing difficult and leading to distressing symptoms.
Asthma is classified as allergic and non-allergic. Allergens such as dust mites, pollen, and pet dander trigger allergic asthma, while factors like cold air, intense emotions, or exercise can induce non-allergic asthma.
Asthma-IV: Diagnostic and Management01:30

Asthma-IV: Diagnostic and Management

The diagnosis and management of asthma are comprehensive, encompassing clinical assessments, lung function tests, and pharmacological interventions. Here's an overview:
Clinical Assessment for Asthma:
This is the first step in diagnosing and managing asthma. It includes:
Proteomics01:33

Proteomics

A proteome is the entire set of proteins that a cell type produces. We can study proteomes using the knowledge of genomes because genes code for mRNAs, and the mRNAs encode proteins. Although mRNA analysis is a step in the right direction, not all mRNAs are translated into proteins.
Proteomics is the study of proteomes' function. It involves the large-scale systematic study of the proteome to denote the protein complement expressed by a genome. Scientist Mark Wilkins coined the term proteomics...
Asthma-I: Introduction01:29

Asthma-I: Introduction

Asthma is a chronic respiratory ailment that requires careful management due to its varying symptoms and influencing factors. It is characterized by airway inflammation, bronchial hyperresponsiveness, and reversible airflow obstruction, leading to symptoms like wheezing, shortness of breath, chest tightness, and coughing. The symptom frequency and intensity may vary considerably over time. It is also linked to immune system responses to allergens and irritants, highlighting the complex...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Glucocorticoids in pregnancy: A master-switch for fetal maturation.

Endocrine reviews·2026
Same author

A Phase 1 Prognostic Trial for Predicting Paediatric Allergy Using the Placenta at Birth.

Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology·2026
Same author

Prevalence, Severity and Impact of Foot Pain in 419 Pregnant Participants: The Queensland Family Cohort Study.

Journal of foot and ankle research·2026
Same author

Queensland Family Cohort Sub-Study: The effects of physical activity throughout pregnancy on maternal lumbopelvic musculoskeletal health.

Journal of science and medicine in sport·2025
Same author

'Gudhurr-wutu' (strengthen the mob): maximizing the impact of First Nations health and well-being messaging.

Health promotion international·2025
Same author

An allele-resolved nanopore-guided tour of the human placental methylome.

Nature communications·2025
Same journal

Dendritic cell subsets in alopecia areata: focus on plasmacytoid dendritic cells and Langerhans cells in immune imbalance and therapeutic implications.

Expert review of clinical immunology·2026
Same journal

The role of immunosenescence and chronic medical conditions on the immune response to respiratory syncytial virus in older individuals.

Expert review of clinical immunology·2026
Same journal

Flow cytometry-based basophil and mast cell activation tests for IgE-mediated food and drug allergy: have we crossed the Rubicon?

Expert review of clinical immunology·2026
Same journal

An update on the pharmacotherapy of ANCA-associated vasculitis.

Expert review of clinical immunology·2026
Same journal

Targeting the cytokine storm: new therapies in the treatment of pediatric hemophagocytic lymphohistiocytosis.

Expert review of clinical immunology·2026
Same journal

Why is the antigen uptake receptor DEC205 (CD205) of interest?

Expert review of clinical immunology·2026
See all related articles

Related Experiment Video

Updated: Jun 13, 2026

Murine Model of Allergen Induced Asthma
08:05

Murine Model of Allergen Induced Asthma

Published on: May 14, 2012

Proteomics in asthma.

Annette Osei-Kumah1, Nicolette Hodyl, Vicki L Clifton

  • 1Discipline of Obstetrics and Gynaecology, School of Paediatrics and Reproductive Health, University of Adelaide, SA 5005, Australia. annette.osei-kumah@adelaide.edu.au

Expert Review of Clinical Immunology
|May 19, 2010
PubMed
Summary
This summary is machine-generated.

Proteomics offers insights into asthma by identifying key proteins. Further research combining animal models and human tissues is crucial for understanding asthma

More Related Videos

A Reversible, Non-invasive Method for Airway Resistance Measurements and Bronchoalveolar Lavage Fluid Sampling in Mice
09:58

A Reversible, Non-invasive Method for Airway Resistance Measurements and Bronchoalveolar Lavage Fluid Sampling in Mice

Published on: April 13, 2010

Related Experiment Videos

Last Updated: Jun 13, 2026

Murine Model of Allergen Induced Asthma
08:05

Murine Model of Allergen Induced Asthma

Published on: May 14, 2012

A Reversible, Non-invasive Method for Airway Resistance Measurements and Bronchoalveolar Lavage Fluid Sampling in Mice
09:58

A Reversible, Non-invasive Method for Airway Resistance Measurements and Bronchoalveolar Lavage Fluid Sampling in Mice

Published on: April 13, 2010

Area of Science:

  • Biochemistry
  • Pulmonology
  • Genomics

Background:

  • Proteomic approaches are established in cancer research but underexplored in asthma.
  • Asthma is a complex respiratory disease with incompletely understood molecular mechanisms.
  • Few studies have investigated protein profiles associated with asthma, especially in human tissues.

Purpose of the Study:

  • To review current literature on proteomic techniques applied to asthma research.
  • To identify proteins contributing to altered lung function in asthma.
  • To explore the potential of proteomics in discovering novel therapeutic targets for asthma.

Main Methods:

  • Literature review of published proteomic studies related to asthma.
  • Analysis of studies utilizing proteomic techniques on animal models and human asthma tissues.
  • Examination of proteomics as a complementary method for candidate protein verification.

Main Results:

  • Most published proteomic studies on asthma have utilized animal models.
  • A limited number of studies have analyzed protein profiles from human asthma tissues.
  • Proteomic analyses have identified potential candidate proteins and novel therapeutic targets for asthma.

Conclusions:

  • Proteomics can significantly contribute to understanding asthma's complexity despite challenges.
  • Future research requires collaboration and validation of findings from animal models in human tissues.
  • Advancing asthma etiology understanding and developing new therapies depend on integrated proteomic studies.