Related Experiment Video
Updated: Jun 13, 2026

Primary Culture of Rat Adrenocortical Cells and Assays of Steroidogenic Functions
Published on: March 12, 2019
Effects of inhaled steroids on growth, bone metabolism and adrenal function
1University of Wisconsin Children's Hospital, H4/448 CSC - Pediatrics, 600 Highland Avenue, Madison, WI 53792, USA. dballen@wisc.edu
Abstract:
Inhaled corticosteroids are a first-line therapy for persistent asthma in children. Major safety concerns of long-term inhaled corticosteroid therapy include suppression of adrenal function, growth and bone development. Proper interpretation of inhaled corticosteroid safety studies requires knowledge of the differences among various inhaled corticosteroid drug/delivery device systems. Dosage, type of inhaler device used, patient technique and characteristics of the individual drug influence the systemic effects of inhaled corticosteroids. Systemic side effects can occur when continuous high-dose treatment is required for severe asthma or when the dosage prescribed is excessive and compliance unusually good. Overall, however, recent studies confirm that benefits of inhaled corticosteroids, properly prescribed and used, clearly outweigh not only their potential adverse effects, but also the risks associated with poorly controlled asthma.
Related Concept Videos
Antiasthma Drugs: Inhaled Corticosteroids and Glucocorticoids
ICS work through a multifaceted mechanism of action. They suppress the inflammatory response caused by the proliferation of TH cells. They also reduce the transcription of the IL-2 gene, which is involved in the...
Hormones of the Adrenal Glands
The adrenal cortex, a powerhouse of hormone synthesis, generates over two dozen corticosteroid hormones. The zona glomerulosa produces mineralocorticoids, exemplified by aldosterone, influencing the electrolyte composition of body fluids. The synthesis of glucocorticoids such as cortisol and corticosterone...
Adrenal Gland Disorders
Adrenal insufficiency, characterized by insufficient cortisol and aldosterone production, leads to conditions like Addison's disease. This disorder, affecting the adrenal cortex, exhibits symptoms such as skin bronzing, dehydration, low blood pressure, fatigue, and weight loss. Congenital adrenal hyperplasia, a genetic ailment causing...
Antiasthma Drugs: β2-Adrenoceptor Agonists
One class of bronchodilators includes β2-adrenoceptor agonists. These agents target the β2-adrenoceptors located on bronchial smooth muscle cells. By stimulating these receptors, β2-agonists induce relaxation in these...
Nature and Nurture
COPD: Management Using Bronchodilators and Corticosteroids
