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Related Concept Videos

Asthma-II: Pathophysiology and Classification01:26

Asthma-II: Pathophysiology and Classification

Asthma is a prevalent chronic respiratory condition marked by inflammation and hyperresponsiveness of the airways. Its pathophysiology involves complex interactions among inflammatory pathways, immune responses, and neural mechanisms.
Additionally, environmental and genetic factors play crucial roles in determining an individual's susceptibility to asthma and the severity of their condition.
Critical processes in asthma pathophysiology include:
Asthma I: Introduction01:28

Asthma I: Introduction

Asthma is a chronic inflammatory disorder of the airways characterized by variable airflow obstruction and heightened bronchial responsiveness to a wide range of triggers. The underlying inflammation leads to airway swelling, mucus hypersecretion, and smooth muscle constriction, all of which narrow the airway lumen and impede airflow. Clinically, asthma presents with recurrent episodes of wheezing, shortness of breath, chest tightness, and coughing, symptoms that typically vary in intensity and...
Immunological Memory01:23

Immunological Memory

Immunological memory, a pivotal pillar of the adaptive immune system, is responsible for the body's ability to remember and respond more swiftly and effectively to previously encountered pathogens. This remarkable feature is what makes vaccines so effective in preventing diseases.
What is Immunological Memory?
Immunological memory is an integral function of the immune system that allows it to recognize and react more rapidly and effectively to pathogens previously encountered. This feature is...
Asthma: Pathogenesis and Management01:20

Asthma: Pathogenesis and Management

Asthma is a chronic pulmonary condition involving inflammation of the airways, hyper-reactivity, and reversible obstruction of the airways. This condition can significantly impact a person's quality of life, making breathing difficult and leading to distressing symptoms.
Asthma is classified as allergic and non-allergic. Allergens such as dust mites, pollen, and pet dander trigger allergic asthma, while factors like cold air, intense emotions, or exercise can induce non-allergic asthma.
Vaccines01:21

Vaccines

Vaccines are among the most effective tools in preventive medicine, designed to prepare the immune system to recognize and combat infectious agents. By introducing antigens—substances that the immune system identifies as foreign—vaccines stimulate an adaptive immune response that leads to immunological memory. This immunological memory enables the body to mount a faster and more effective response upon future exposures to the actual pathogen.Vaccines can be categorized based on the type of...
Asthma-I: Introduction01:29

Asthma-I: Introduction

Asthma is a chronic respiratory ailment that requires careful management due to its varying symptoms and influencing factors. It is characterized by airway inflammation, bronchial hyperresponsiveness, and reversible airflow obstruction, leading to symptoms like wheezing, shortness of breath, chest tightness, and coughing. The symptom frequency and intensity may vary considerably over time. It is also linked to immune system responses to allergens and irritants, highlighting the complex...

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Related Experiment Video

Updated: Jun 13, 2026

Identification of Rare Antigen-Specific T Cells from Mouse Lungs with Peptide:Major Histocompatibility Complex Tetramers
09:15

Identification of Rare Antigen-Specific T Cells from Mouse Lungs with Peptide:Major Histocompatibility Complex Tetramers

Published on: July 19, 2024

Pathogens and immunologic memory in asthma: what have we learned?

Mark A Aronica1, Nicola Vogel

  • 1Cleveland Clinic Foundation, Department of Pulmonary, Allergy and Critical Care Medicine, Cleveland, OH 44195, USA. aronicm@ccf.org

Expert Review of Clinical Immunology
|May 19, 2010
PubMed
Summary

This review explores how infections and memory T-cells contribute to asthma development and persistence. Understanding these links is key to managing chronic allergic airway disease.

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Murine Model of Allergen Induced Asthma
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Published on: May 14, 2012

Related Experiment Videos

Last Updated: Jun 13, 2026

Identification of Rare Antigen-Specific T Cells from Mouse Lungs with Peptide:Major Histocompatibility Complex Tetramers
09:15

Identification of Rare Antigen-Specific T Cells from Mouse Lungs with Peptide:Major Histocompatibility Complex Tetramers

Published on: July 19, 2024

Advanced Imaging of Lung Homing Human Lymphocytes in an Experimental In Vivo Model of Allergic Inflammation Based on Light-sheet Microscopy
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Advanced Imaging of Lung Homing Human Lymphocytes in an Experimental In Vivo Model of Allergic Inflammation Based on Light-sheet Microscopy

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Murine Model of Allergen Induced Asthma
08:05

Murine Model of Allergen Induced Asthma

Published on: May 14, 2012

Area of Science:

  • Immunology
  • Respiratory Medicine
  • Allergy

Background:

  • Asthma pathogenesis involves an initial effector phase and less understood chronic mechanisms.
  • CD4(+) T-helper 2 lymphocytes initiate allergic airway inflammation.
  • Memory T-cells and pathogen involvement are increasingly recognized in asthma persistence and exacerbations.

Purpose of the Study:

  • To review the potential links between infection and asthma.
  • To discuss the role of memory T-cells in asthma.
  • To explore mechanisms of asthma development and persistence involving these factors.

Main Methods:

  • Literature review of animal models and clinical studies.
  • Analysis of immunological mechanisms in asthma.
  • Synthesis of evidence on infection, memory T-cells, and asthma.

Main Results:

  • CD4(+) T-helper 2 cells are key initiators of allergic asthma.
  • Memory T-cells sensitized to various antigens contribute to asthma persistence.
  • Pathogens are implicated in both asthma susceptibility and disease flares.

Conclusions:

  • Infections and memory T-cells are critical factors in asthma pathogenesis.
  • Understanding the interaction between infection and memory T-cells is vital for addressing asthma chronicity.
  • Further research into these mechanisms may reveal new therapeutic targets for persistent asthma.