Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Small-duct primary sclerosing cholangitis.

J Ludwig1

  • 1Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, Minnesota 55905.

Seminars in Liver Disease
|February 1, 1991
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

OrthoRefine: automated enhancement of prior ortholog identification via synteny.

BMC bioinformatics·2024
Same author

A flexible proton beam imaging energy spectrometer (PROBIES) for high repetition rate or single-shot high energy density (HED) experiments (invited).

The Review of scientific instruments·2023
Same author

A critical evaluation of the material properties and clinical suitability of in-house printed and commercial tooth replicas for endodontic training.

International endodontic journal·2020
Same author

Long spin-flip time and large Zeeman splitting of holes in type-II ZnTe/ZnSe submonolayer quantum dots.

Journal of applied physics·2019
Same author

Treatment of old neglected dislocations of the AC-joint with residual instability and/or secondary osteoarthrosis.

Der Orthopade·2017
Same author

Surgical treatment of lumbar disc herniation. Indication and methods.

Der Orthopade·2017
Same journal

Endothelial Cell Therapy for the Acute and Chronic Liver Disease.

Seminars in liver disease·2026
Same journal

Neutrophils in Liver Diseases: Functions and Challenging Therapies.

Seminars in liver disease·2026
Same journal

Expert Practical Recommendations for Hepatocellular Carcinoma.

Seminars in liver disease·2026
Same journal

Optimizing Liver Cancer Care Through BCLC Principles.

Seminars in liver disease·2026
Same journal

Patient-Derived Models of Liver Cancer to Inform Clinical Treatment Paradigms: Recent Updates.

Seminars in liver disease·2026
Same journal

Practical Guide to Best Practices in Alcohol-Associated Liver Disease.

Seminars in liver disease·2026
See all related articles

Small-duct primary sclerosing cholangitis (PSC) may affect the entire biliary system. Its features are crucial for staging PSC, highlighting the need for further research into its incidence and pathogenesis.

Area of Science:

  • Hepatology
  • Gastroenterology
  • Biliary Medicine

Background:

  • Primary sclerosing cholangitis (PSC) can impact the entire biliary tree.
  • Distinguishing between small-duct and large-duct PSC is essential for accurate diagnosis and management.
  • The term "small-duct PSC" is proposed to replace "pericholangitis" due to clearer definition.

Purpose of the Study:

  • To redefine the scope of primary sclerosing cholangitis (PSC) by emphasizing the role of small-duct PSC.
  • To establish small-duct PSC features as the basis for PSC disease staging.
  • To highlight the clinical significance of small-duct PSC in the overall PSC syndrome.

Main Methods:

  • Review of current evidence on PSC pathology and clinical presentation.
  • Comparative analysis of small-duct and large-duct PSC characteristics.

Related Experiment Videos

  • Conceptual framework development for PSC staging based on small-duct disease.

    • Main Results:

    • Small-duct PSC affects bile ducts too small for cholangiography, while large-duct PSC involves identifiable duct changes.
    • Small-duct PSC can coexist with or occur independently of large-duct PSC.
    • Hepatic changes related to small-duct PSC, not large-duct disease, primarily dictate patient outcomes.

    Conclusions:

    • Small-duct PSC is a critical component of the PSC syndrome, influencing disease progression and clinical course.
    • The features and complications of small-duct PSC should be utilized for staging PSC.
    • Further research is imperative to determine the incidence, natural history, and pathogenesis of small-duct PSC.