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Benefits of Cardiac Resynchronization Therapy in an Asynchronous Heart Failure Model Induced by Left Bundle Branch Ablation and Rapid Pacing
12:45

Benefits of Cardiac Resynchronization Therapy in an Asynchronous Heart Failure Model Induced by Left Bundle Branch Ablation and Rapid Pacing

Published on: December 11, 2017

Clinical and echocardiographic correlates of improvement in left ventricular diastolic function after cardiac

Hakan Aksoy1, Sercan Okutucu, Ergun Baris Kaya

  • 1Department of Cardiology, Hacettepe University Faculty of Medicine, Sihhiye/Ankara 06100, Turkey.

Europace : European Pacing, Arrhythmias, and Cardiac Electrophysiology : Journal of the Working Groups on Cardiac Pacing, Arrhythmias, and Cardiac Cellular Electrophysiology of the European Society of Cardiology
|May 19, 2010
PubMed

Insights

Cardiac resynchronization therapy (CRT) improves diastolic function in heart failure (HF) responders. Improvement in left ventricular (LV) diastolic indices after CRT is linked to reduced brain natriuretic peptide (BNP) levels.

Area of Science:

  • Cardiology
  • Heart Failure Management
  • Echocardiography

Background:

  • Cardiac resynchronization therapy (CRT) is known to enhance systolic function in heart failure (HF) patients.
  • However, the impact of CRT on left ventricular (LV) diastolic function remains incompletely understood.

Purpose of the Study:

  • To investigate the clinical and echocardiographic factors associated with improvements in LV diastolic function following CRT.
  • To analyze the relationship between changes in diastolic function and plasma brain natriuretic peptide (BNP) levels post-CRT.

Main Methods:

  • Fifty-four severe HF patients underwent CRT.
  • Echocardiographic assessments included pulsed-wave Doppler mitral inflow, color M-mode flow propagation, and tissue Doppler imaging (TDI) for diastolic (e') velocities and E/e' ratio.
  • Plasma BNP levels were measured pre-CRT, with CRT response defined as a >=10% decline in LV end-systolic volume.

Main Results:

  • Responder patients showed significant improvements in septal E/e', E/Vp, left atrial volume index (LAVI), and plasma BNP levels.
  • Non-responders did not exhibit significant changes in diastolic function indices or BNP levels.
  • Spearman's correlation revealed negative correlations between the decline in BNP and improvements in septal E/e', E/Vp, and LAVI.

Conclusions:

  • CRT leads to improved LV diastolic indices in HF patients who respond to therapy.
  • The degree of improvement in diastolic function post-CRT is associated with a reduction in plasma BNP levels.
Abstract

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