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Related Concept Videos

Combination Therapies and Personalized Medicine02:50

Combination Therapies and Personalized Medicine

Combining two or more treatment methods increases the life span of cancer patients while reducing damage to vital organs or tissue from the overuse of a single treatment. Combination therapy also targets different cancer-inducing pathways, thus reducing the chances of developing resistance to treatment.
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...
Combination Therapies and Personalized Medicine02:50

Combination Therapies and Personalized Medicine

Combining two or more treatment methods increases the life span of cancer patients while reducing damage to vital organs or tissue from the overuse of a single treatment. Combination therapy also targets different cancer-inducing pathways, thus reducing the chances of developing resistance to treatment.
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...
Targeted Cancer Therapies02:57

Targeted Cancer Therapies

The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against specific...
Targeted Cancer Therapies02:57

Targeted Cancer Therapies

The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against specific...
Tumor Immunotherapy01:27

Tumor Immunotherapy

Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.
Cancer Therapies02:49

Cancer Therapies

Cancer therapies are various modes of treatment, such as surgery, radiation therapy, and chemotherapy that are administered to cancer patients.
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...

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Related Experiment Video

Updated: Jun 13, 2026

A Robust Discovery Platform for the Identification of Novel Mediators of Melanoma Metastasis
07:41

A Robust Discovery Platform for the Identification of Novel Mediators of Melanoma Metastasis

Published on: March 8, 2022

Multiobjective optimization based-approach for discovering novel cancer therapies.

Arthur W Mahoney1, Gregory J Podgorski, Nicholas S Flann

  • 1Utah State University, Logan.

IEEE/ACM Transactions on Computational Biology and Bioinformatics
|May 19, 2010
PubMed
Summary

This study developed a simulation to find new cancer treatments that block tumor blood vessel growth (angiogenesis). The approach identified existing therapies and novel strategies for inhibiting angiogenesis.

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Genetic Profiling and Genome-Scale Dropout Screening to Identify Therapeutic Targets in Mouse Models of Malignant Peripheral Nerve Sheath Tumor
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Genetic Profiling and Genome-Scale Dropout Screening to Identify Therapeutic Targets in Mouse Models of Malignant Peripheral Nerve Sheath Tumor

Published on: August 25, 2023

Area of Science:

  • Oncology
  • Computational Biology
  • Biomedical Engineering

Background:

  • Solid tumors require new blood vessel formation (angiogenesis) for growth and survival.
  • Inhibiting tumor angiogenesis is a key strategy in cancer therapy.
  • Current anti-angiogenesis therapies, like blocking VEGF, are effective but limited by complexity.

Purpose of the Study:

  • To develop a high-fidelity simulation of angiogenesis.
  • To utilize a search-based approach for discovering novel cancer treatments targeting angiogenesis.
  • To optimize interventions by balancing development cost and simulated tumor oxygenation.

Main Methods:

  • Development of a sophisticated angiogenesis simulation model.
  • Application of a parallel search-based algorithm for drug discovery.
  • Multiobjective combinatorial optimization to identify effective anti-angiogenic strategies.

Main Results:

  • The search process successfully identified known anti-angiogenic interventions.
  • Novel, nonintuitive therapeutic approaches for inhibiting blood vessel growth were discovered.
  • The simulation-based approach proved effective in uncovering new treatment possibilities.

Conclusions:

  • A computational approach using high-fidelity angiogenesis simulation can accelerate the discovery of cancer therapies.
  • Optimizing interventions based on cost and efficacy provides a powerful framework for identifying novel treatments.
  • This method holds promise for uncovering nonintuitive yet effective strategies against tumor angiogenesis.