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Related Concept Videos

Inflammation01:38

Inflammation

Overview
Inflammatory Response01:28

Inflammatory Response

An inflammatory response is a localized, nonspecific immune reaction that occurs when a tissue is injured. It is characterized by redness, swelling, heat, and pain, which are commonly called the cardinal signs and symptoms of inflammation. Inflammation can sometimes result in a loss of function.
Inflammation can be triggered by various stimuli, such as impact, abrasion, chemical irritation, infections, and extreme hot or cold temperatures. These can damage cells and connective tissue fibers,...
Acute Inflammation I: Inflammatory Response01:26

Acute Inflammation I: Inflammatory Response

Acute inflammation is a rapid, short-lived physiological response to tissue injury or infection, designed to eliminate harmful agents and initiate repair. This tightly regulated process typically lasts from minutes to several days and is triggered by factors such as microbial invasion, physical trauma, or chemical injury.Recognition and Mediator ReleaseThe inflammatory response begins when resident immune cells—such as mast cells, macrophages, and dendritic cells—detect damage-associated...
Inflammation: Introduction01:28

Inflammation: Introduction

Inflammation is a fundamental, protective biological response of vascularized tissues to cellular injury, infection, or harmful stimuli. Its primary function is to eliminate the initial cause of injury, clear necrotic cells and damaged tissue, and initiate the necessary repair processes.Cardinal SignsAcute inflammation presents with classic signs. Redness results from vasodilation and increased blood flow. Heat is due to increased metabolism and circulation. Swelling results from the...
Inflammatory Response I: Vascular and Cellular01:30

Inflammatory Response I: Vascular and Cellular

The inflammatory response is the body's defense against infection, injury, or irritation from bacteria, trauma, toxins, or heat. Inflammation helps locate and destroy pathogens and remove damaged tissue elements to heal the body. During this initial phase, fluid, blood products, and nutrients migrate to the injured area, resulting in redness, heat, swelling, ache, and loss of function. Moreover, signs of systemic inflammation include fever, increased WBC count, malaise, anorexia, nausea,...
Asthma-II: Pathophysiology and Classification01:26

Asthma-II: Pathophysiology and Classification

Asthma is a prevalent chronic respiratory condition marked by inflammation and hyperresponsiveness of the airways. Its pathophysiology involves complex interactions among inflammatory pathways, immune responses, and neural mechanisms.
Additionally, environmental and genetic factors play crucial roles in determining an individual's susceptibility to asthma and the severity of their condition.
Critical processes in asthma pathophysiology include:

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Related Experiment Video

Updated: Jun 13, 2026

Analyzing the Functions of Mast Cells In Vivo Using 'Mast Cell Knock-in' Mice
09:07

Analyzing the Functions of Mast Cells In Vivo Using 'Mast Cell Knock-in' Mice

Published on: May 27, 2015

Mast cells in cutaneous inflammatory disorders.

N A Soter1

  • 1Department of Dermatology, Harvard Medical School, and Immunodermatology Section, Department of Rheumatology and Immunology, and Division of Dermatology, Department of Medicine, Rrigham and Women's Hospital, Boston, Massachusetts, U.S.A.

The Journal of Investigative Dermatology
|May 19, 2010
PubMed
Summary
This summary is machine-generated.

Skin mast cells release mediators that cause biphasic responses, potentially leading to urticaria/angioedema or chronic inflammatory skin diseases like necrotizing vasculitis.

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Investigating Mast Cell Secretory Granules; from Biosynthesis to Exocytosis
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Investigating Mast Cell Secretory Granules; from Biosynthesis to Exocytosis

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Published on: May 27, 2015

Isolation of Peritoneum-derived Mast Cells and Their Functional Characterization with Ca2+-imaging and Degranulation Assays
11:31

Isolation of Peritoneum-derived Mast Cells and Their Functional Characterization with Ca2+-imaging and Degranulation Assays

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Investigating Mast Cell Secretory Granules; from Biosynthesis to Exocytosis
16:01

Investigating Mast Cell Secretory Granules; from Biosynthesis to Exocytosis

Published on: January 26, 2015

Area of Science:

  • Dermatology
  • Immunology
  • Cell Biology

Background:

  • Mast cells in skin are strategically located near blood vessels.
  • Their activation releases diverse biologically active molecules.

Purpose of the Study:

  • To elucidate the role of mast cell mediators in skin inflammation.
  • To understand the progression from acute to chronic inflammatory conditions.

Main Methods:

  • Review of mast cell mediator functions.
  • Analysis of clinical manifestations and histologic findings in conditions like urticaria and necrotizing vasculitis.
  • Case study involving physical stimuli (cold, trauma) and mast cell degranulation.

Main Results:

  • Mast cell mediators induce biphasic responses: an initial humoral phase (vascular permeability) and a cellular phase (leukocyte recruitment).
  • Failure to control these phases can lead to urticaria/angioedema or chronic inflammatory skin injury.
  • Physical urticaria serves as a model to study these mechanisms.

Conclusions:

  • Mast cell activation is central to acute and chronic inflammatory skin diseases.
  • Understanding mast cell mediator roles is crucial for diagnosing and treating conditions like necrotizing vasculitis.