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Related Experiment Video

Updated: Jun 13, 2026

A Microfluidic Platform for Precision Small-volume Sample Processing and Its Use to Size Separate Biological Particles with an Acoustic Microdevice
11:32

A Microfluidic Platform for Precision Small-volume Sample Processing and Its Use to Size Separate Biological Particles with an Acoustic Microdevice

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Hydrodynamic gating for sample introduction on a microfluidic chip.

Pu Chen1, Xiaojun Feng, Jian Sun

  • 1Britton Chance Center for Biomedical Photonics at Wuhan National Laboratory for Optoelectronics - Hubei Bioinformatics & Molecular Imaging Key Laboratory, Department of Systems Biology, College of Life Science and Technology, Huazhong University of Science and Technology, Wuhan, 430074, China.

Lab on a Chip
|May 19, 2010
PubMed
Summary
This summary is machine-generated.

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We developed a hydrodynamic gated injection method for microfluidic systems. This technique offers precise, repeatable picoliter sample delivery ideal for live biological analysis.

Area of Science:

  • Biotechnology
  • Microfluidics
  • Analytical Chemistry

Background:

  • Microfluidic devices require precise sample introduction for accurate analysis.
  • Existing methods like electrokinetic injection have limitations in driving force and biocompatibility.

Purpose of the Study:

  • To introduce a novel hydrodynamic gated injection technique for microfluidic sample introduction.
  • To validate the method's performance and assess its suitability for live biological samples.

Main Methods:

  • Development of a hydrodynamic gating mechanism for flow control.
  • Numerical simulations and flow visualization experiments for theoretical validation.
  • Picoliter sample injection experiments using fluorescein and GFP-transfected nematode eggs.

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Last Updated: Jun 13, 2026

A Microfluidic Platform for Precision Small-volume Sample Processing and Its Use to Size Separate Biological Particles with an Acoustic Microdevice
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Published on: November 23, 2015

A Microfluidic-based Hydrodynamic Trap for Single Particles
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A Microfluidic-based Hydrodynamic Trap for Single Particles

Published on: January 21, 2011

A Microfluidic Chip for ICPMS Sample Introduction
11:16

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Main Results:

  • Demonstrated easy and flexible flow control with a strong driving force.
  • Achieved high repeatability (RSD <1.9%) for picoliter sample injections.
  • Confirmed excellent biocompatibility with >95% survival rate for injected nematode eggs.

Conclusions:

  • Hydrodynamic gated injection is a robust method for microfluidic sample introduction.
  • The technique is suitable for analyzing live biological samples due to its biocompatibility.
  • This method can be integrated into microfluidic systems for cell and organism analysis.