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Updated: Jun 12, 2026

Aptamer-Based Target Detection Facilitated by a 3-Stage G-Quadruplex Isothermal Exponential Amplification Reaction
Published on: October 6, 2022
Aptamer-based carbohydrate recognition
Wei Sun1, Lupei Du, Minyong Li
1Department of Medicinal Chemistry, School of Pharmacy, Shandong University, Jinan, Shandong, 250012, China.
Abstract:
Carbohydrates have been revealed to play fundamental roles in diverse biological phenomena, such as being recognition sites and biomarkers. Recently, ample nucleic acid aptamers guided for carbohydrate recognition have already been isolated and characterized through SELEX methodology. This review would like to present and discuss these aptamers toward recognizing various carbohydrate targets: monosaccharides, oligosaccharides, polysaccharides, aminoglycoside antibiotics and glycans from glycoproteins. High affinity carbohydrate aptamers that we reviewed herein might shed light on the development of a tool to augment drug discovery creations.

