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Updated: Jun 12, 2026

Induction and Clinical Scoring of Chronic-Relapsing Experimental Autoimmune Encephalomyelitis
Published on: July 4, 2007
Progressive multifocal leucoencephalopathy in an immunocompetent patient with favourable outcome. A case report
Halvor Naess1, Solveig Glad, Anette Storstein
1Department of Neurology, Haukeland University Hospital, N-5021 Bergen, Norway. haln@haukeland.no
Background:
To report the clinical course of PML in an apparently immunocompetent patient treated with cidofovir.
Case Presentation:
A 35-year-old immunocompetent man who developed progressive hemianopsia, aphasia, and limb weakness underwent repeated MRI scans of the brain, spinal fluid analyses, and brain biopsy. Before diagnosis was established based on brain biopsy, he was consecutively treated with methylprednisolone, acyclovir, ceftriaxone and plasmapheresis, but he deteriorated rapidly suggestive of the immune reconstitution inflammatory syndrome (IRIS). He started to recover two weeks after the initiation of treatment with cidofovir and has had no relapse at 3 1/2 years of follow-up. MRI has shown marked improvement.
Conclusions:
PML should be considered in immunocompetent patients with a typical clinical course and MRI findings compatible with PML. Treatment with cidofovir should be considered as early as possible in the disease course.
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