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Updated: Jun 12, 2026
07:32
Screening and Identification of Small Peptides Targeting Fibroblast Growth Factor Receptor2 using a Phage Display Peptide Library
Published on: September 30, 2019
[Fibroblast growth factor 23--a phosphate regulating hormone].
Signe Sparre Beck-Nielsen1, Susanne Møller Pedersen, Moustapha Kassem
1H.C. Andersen Børnehospital, Afdeling for Biokemi, Farmakologi og Genetik, Odense Universitetshospital, 5000 Odense C, Denmark. sbeck-nielsen@dadlnet.dk
Ugeskrift for Laeger
|May 21, 2010
Summary
Fibroblast growth factor 23 (FGF23) is a key phosphatonin regulating phosphate and vitamin D. Measuring FGF23 aids in diagnosing conditions like hypophosphatemic rickets and tumoral calcinosis.
Area of Science:
- Endocrinology
- Mineral Metabolism
Background:
- Fibroblast growth factor 23 (FGF23) is a recently identified phosphatonin.
- FGF23 plays a crucial role in maintaining serum phosphate homeostasis.
- It also counter-regulates the physiological effects of vitamin D.
Purpose of the Study:
- To highlight the diagnostic utility of FGF23 measurements.
- To differentiate between various conditions affecting phosphate and vitamin D metabolism.
Main Methods:
- Analysis of serum FGF23 levels.
- Correlation of FGF23 levels with specific disease phenotypes.
Main Results:
- High FGF23 levels are associated with hypophosphatemic rickets, fibrous dysplasia, and tumor-induced osteomalacia.
- Accelerated FGF23 degradation is linked to hyperphosphatemic tumoral calcinosis.
- FGF23 measurement is a valuable tool for diagnosing hypophosphatemia.
Conclusions:
- FGF23 is a critical regulator of phosphate and vitamin D.
- Serum FGF23 levels are important biomarkers for diagnosing mineral metabolism disorders.
- FGF23 testing aids in the differential diagnosis of hypophosphatemia.
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