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Published on: October 27, 2023
Mesenchymal phosphaturic neoplasm in the maxillary sinus: a case report
M Pedrazzoli1, G Colletti, M Ferrari
1Department of Maxillo-Facial Surgery, San Paolo Hospital, University of Milan, Via A. Di Rudinì 8, Milan, Italy. marcomxf@gmail.com
Summary
A rare case of oncogenic osteomalacia, a bone disease caused by a specific tumor, was successfully treated. Surgical removal of the maxillary sinus tumor resolved the debilitating symptoms of this paraneoplastic syndrome.
Area of Science:
- Endocrinology
- Oncology
- Pathology
Background:
- Oncogenic osteomalacia is a rare paraneoplastic syndrome.
- It results from a tumor producing phosphatonin, leading to phosphate wasting.
- This causes severe bone pain, muscle weakness, and fractures.
Observation:
- A patient presented with muscle stiffness, hypotonia, weight loss, and pathological fractures.
- Clinical and radiological exams identified a maxillary sinus tumor.
- Pathology confirmed a mesenchymal phosphaturic tumor with a hemangiopericytoma-like vascular pattern.
Findings:
- The tumor was the cause of oncogenic osteomalacia.
- Mesenchymal tumors in the paranasal sinuses are uncommon.
- Surgical excision of the tumor led to rapid clinical improvement.
Implications:
- Early diagnosis and surgical removal are crucial for treating oncogenic osteomalacia.
- This case highlights the importance of considering rare tumor locations for paraneoplastic syndromes.
- Further research into phosphatonin-secreting tumors can improve patient outcomes.
