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Differential Effects of Lipid-lowering Drugs in Modulating Morphology of Cholesterol Particles
Published on: November 10, 2017
Aging men and lipids
Genovefa Kolovou1, Helen Bilianou, Apostolia Marvaki
1Onassis Cardiac Surgery Center, Athens, Greece.
American Journal of Men'S Health
|May 21, 2010
Summary
Aging men experience decreased androgens, impacting lipid profiles negatively. This review examines how age affects male lipid metabolism, contributing to higher atherogenesis risk.
Area of Science:
- Endocrinology
- Gerontology
- Metabolism
Background:
- Natural aging in men is associated with declining levels of androgens, growth hormone, and insulin-like growth factor.
- Androgens play a crucial role in male development and maturation, with their actions mediated by androgen receptors.
- Previous research indicates androgens negatively affect lipid profiles in men, a factor contributing to higher atherogenesis rates compared to women.
Purpose of the Study:
- To review the influence of aging on lipid metabolism specifically in men.
- To explore the relationship between declining androgen levels and altered lipid profiles in aging males.
- To understand the mechanisms linking androgens, lipid metabolism, and atherogenesis in the context of male aging.
Main Methods:
- Literature review focusing on studies investigating aging, androgens, and lipid metabolism in men.
- Analysis of research on the role of androgen receptors in mediating androgen effects on lipid profiles.
- Synthesis of findings regarding the differential impact of androgens and estrogens on atherogenesis.
Main Results:
- Aging in men is characterized by decreased androgen levels, which exacerbates negative effects on lipid profiles.
- The influence of androgens on lipid metabolism is more pronounced in aging men, increasing atherogenesis risk.
- Estrogens in women have a positive influence on lipid profiles, contrasting with the negative impact of androgens in men.
Conclusions:
- Age-related decline in androgens significantly impacts male lipid metabolism.
- Understanding these hormonal changes is crucial for addressing the higher prevalence of atherogenesis in aging men.
- This review highlights the critical role of androgens in male lipid homeostasis throughout the aging process.
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