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Updated: Jun 12, 2026
08:55
Murine Model for Non-invasive Imaging to Detect and Monitor Ovarian Cancer Recurrence
Published on: November 2, 2014
Stanniocalcin 1 and ovarian tumorigenesis
Guangzhi Liu1, Gong Yang, Bin Chang
1Department of Pathology, Unit 85, The University of Texas M. D. Anderson Cancer Center, 1515 Holcombe Blvd, Houston, TX 77030, USA.
Journal of the National Cancer Institute
|May 21, 2010
Summary
Stanniocalcin 1 (STC1) is elevated in ovarian cancer and promotes tumor growth by increasing cell proliferation and migration. Inhibiting STC1 with antibodies significantly increases apoptosis in ovarian cancer cells.
Area of Science:
- Oncology
- Molecular Biology
- Biochemistry
Background:
- Stanniocalcin 1 (STC1) is a secreted glycoprotein hormone.
- Elevated STC1 expression is linked to several cancers, including ovarian cancer.
- The precise role of STC1 in ovarian cancer development remains unclear.
Purpose of the Study:
- To investigate the role of Stanniocalcin 1 (STC1) in ovarian tumorigenesis.
- To determine the functional impact of STC1 expression on ovarian cancer cell behavior.
- To assess the therapeutic potential of targeting STC1 in ovarian cancer.
Main Methods:
- Utilized human ovarian cancer cell lines, ovarian cancer tissues, and patient serum.
- Generated STC1-overexpressing and STC1-silenced cells.
- Assessed cell proliferation, migration, colony formation, and apoptosis.
- Studied xenograft tumor growth in mice and employed neutralizing anti-STC1 antibodies.
Main Results:
- STC1 protein expression was significantly higher in ovarian cancer cell lines, tissues, and patient serum compared to controls.
- STC1 overexpression enhanced ovarian cancer cell proliferation, migration, colony formation, and xenograft tumor growth.
- Inhibition of STC1 using neutralizing antibodies increased apoptosis in ovarian cancer cells.
Conclusions:
- STC1 protein plays a significant role in ovarian tumorigenesis.
- STC1 promotes ovarian cancer progression through enhanced proliferation and migration.
- Targeting STC1 presents a potential therapeutic strategy for ovarian cancer.
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