Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Site-Targeted Drug Delivery Systems: Polymeric Carriers01:24

Site-Targeted Drug Delivery Systems: Polymeric Carriers

Polymeric carriers enhance targeted drug delivery by increasing efficacy while minimizing off-target effects. These carriers comprise a biodegradable polymeric backbone integrated with functional elements that enable targeting, improve physicochemical properties, and regulate drug release.Targeting MechanismsThe targeting ability of polymeric carriers is mediated by a homing device, which is a molecular recognition component designed to selectively bind to specific tissues or cells. Monoclonal...
Modified-Release Drug Delivery Systems: Site-Targeted01:24

Modified-Release Drug Delivery Systems: Site-Targeted

Site-targeted drug delivery systems enhance therapeutic efficacy while minimizing systemic toxicity and treatment costs. Unlike conventional methods, these systems ensure precise drug delivery, improving bioavailability and reducing side effects. Targeted drug delivery is classified into three levels. First-order targeting directs drugs to the capillary beds of specific organs or tissues. Second-order targets specific cell types, such as tumor cells, using receptor-mediated interactions.
Modified-Release Drug Delivery Systems: Rate-Programmed II01:19

Modified-Release Drug Delivery Systems: Rate-Programmed II

Rate-programmed drug delivery systems release drugs in a controlled manner to maintain therapeutic levels. Three main designs include reservoir, matrix, and hybrid systems.Reservoir systems consist of a drug core enclosed within a membrane that controls drug release. In non-swelling reservoir systems, polymers like ethyl cellulose or polymethacrylates are used. These do not hydrate in aqueous media and control release through membrane thickness, porosity, or insolubility. This type includes...
Modified-Release Drug Delivery Systems: Stimuli-Activated01:30

Modified-Release Drug Delivery Systems: Stimuli-Activated

Stimuli-activated drug delivery systems are designed to release drugs in response to specific physical, chemical, or biological stimuli. These systems often utilize hydrogels—three-dimensional, hydrophilic polymer networks capable of swelling in aqueous environments and retaining significant fluid volumes. Upon exposure to particular stimuli, these hydrogels undergo structural transitions that allow the embedded drug to be released. Due to this adaptive behavior, such systems are also called...
Modified-Release Drug Delivery Systems: Classification01:23

Modified-Release Drug Delivery Systems: Classification

Modified-release drug delivery systems improve drug efficacy and minimize side effects by controlling the rate and location of drug release. These systems fall into three categories: rate-programmed, stimuli-activated, and site-targeted.Rate-programmed systems release drugs at a predetermined rate, maintaining consistent therapeutic levels and reducing fluctuations that could lead to toxicity or subtherapeutic effects. These systems use polymeric matrices, reservoir-based designs, or osmotic...
Drug Delivery Systems: Different Types01:27

Drug Delivery Systems: Different Types

Conventional oral drug products, termed immediate-release (IR) formulations, are engineered to promptly release their active pharmaceutical ingredient (API) upon ingestion, typically in tablets or capsules. This rapid release often results in swift drug absorption and consequent pharmacodynamic effects, although the timing and intensity can vary depending on the drug's properties. Prodrugs within these formulations require metabolic conversion to activate their pharmacodynamic effects,...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Defect-Guided Assembly of Aperiodic and Flexible Metal-Organic Frameworks From Pre-Formed Cages.

Angewandte Chemie (International ed. in English)·2026
Same author

Weather-Resistant Thermoresponsive UV-Curable Smart Window Composites Based on Paraffin Particles.

ACS applied materials & interfaces·2026
Same author

Supramolecular purification of mono-adamantane mixtures <i>via</i> stabilized three-shell Matryoshka assemblies.

Chemical science·2026
Same author

Ambient one-step synthesis and direct coating of highly crystalline covalent organic frameworks on arbitrary surfaces.

Science advances·2026
Same author

Programmable Pore Environments in Multivariate ZIF Membranes for Ultra-Selective Helium Recovery from Natural Gas.

Journal of the American Chemical Society·2026
Same author

Symmetric Metal Organic Framework-Plasmonic Architectures for Reversible and High-Sensitivity Optical Sensing.

Small (Weinheim an der Bergstrasse, Germany)·2026

Related Experiment Video

Updated: Jun 12, 2026

Formulation of Diblock Polymeric Nanoparticles through Nanoprecipitation Technique
06:47

Formulation of Diblock Polymeric Nanoparticles through Nanoprecipitation Technique

Published on: September 20, 2011

Coordination polymer particles as potential drug delivery systems.

Inhar Imaz1, Marta Rubio-Martínez, Lorena García-Fernández

  • 1Centro de Investigación en Nanociencia y Nanotecnología (ICN-CSIC) Campus UAB, 08193 Bellaterra, Spain.

Chemical Communications (Cambridge, England)
|May 21, 2010
PubMed
Summary

Metal-organic capsules effectively encapsulate and deliver anticancer drugs like doxorubicin. These novel drug delivery systems demonstrate significant potential for cancer treatment by releasing therapeutic agents directly to cancer cells.

More Related Videos

Anionic Polymerization of an Amphiphilic Copolymer for Preparation of Block Copolymer Micelles Stabilized by &#960;-&#960; Stacking Interactions
10:53

Anionic Polymerization of an Amphiphilic Copolymer for Preparation of Block Copolymer Micelles Stabilized by π-π Stacking Interactions

Published on: October 10, 2016

Preparation and Characterization of Individual and Multi-drug Loaded Physically Entrapped Polymeric Micelles
07:32

Preparation and Characterization of Individual and Multi-drug Loaded Physically Entrapped Polymeric Micelles

Published on: August 28, 2015

Related Experiment Videos

Last Updated: Jun 12, 2026

Formulation of Diblock Polymeric Nanoparticles through Nanoprecipitation Technique
06:47

Formulation of Diblock Polymeric Nanoparticles through Nanoprecipitation Technique

Published on: September 20, 2011

Anionic Polymerization of an Amphiphilic Copolymer for Preparation of Block Copolymer Micelles Stabilized by &#960;-&#960; Stacking Interactions
10:53

Anionic Polymerization of an Amphiphilic Copolymer for Preparation of Block Copolymer Micelles Stabilized by π-π Stacking Interactions

Published on: October 10, 2016

Preparation and Characterization of Individual and Multi-drug Loaded Physically Entrapped Polymeric Micelles
07:32

Preparation and Characterization of Individual and Multi-drug Loaded Physically Entrapped Polymeric Micelles

Published on: August 28, 2015

Area of Science:

  • Materials Science
  • Nanotechnology
  • Drug Delivery

Background:

  • Coordination polymers offer potential for drug encapsulation and delivery.
  • Developing effective nanoscale drug delivery systems is crucial for cancer therapy.

Purpose of the Study:

  • To investigate the use of micro- and nanoscale coordination polymer particles for drug delivery.
  • To evaluate the anticancer efficacy of doxorubicin released from these particles.

Main Methods:

  • Synthesis of micro- and nanoscale coordination polymer particles.
  • In vitro cancer cell cytotoxicity assays.
  • Doxorubicin loading and release studies.

Main Results:

  • Coordination polymer particles successfully encapsulated doxorubicin.
  • Released doxorubicin demonstrated significant anticancer efficacy in vitro.
  • The particles facilitated efficient drug release in cancer cells.

Conclusions:

  • Metal-organic capsules show promise as effective drug delivery vehicles.
  • This technology opens new avenues for targeted cancer therapy.
  • Further research into these systems could advance nanomedicine.